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PMID: 18295578 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

Cell ·Vol. 132 ·No. 4 ·2008-02-22 ·Pages 598-611

Morrison SJ, Spradling AC

Abstract

Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although similar single-cell resolution has usually not been achieved in mammalian tissues, principles likely to govern the behavior of niches in diverse organisms are emerging. Considerable progress has been made in elucidating how the microenvironment promotes stem cell maintenance. Mechanisms of stem cell maintenance are key to the regulation of homeostasis and likely contribute to aging and tumorigenesis when altered during adulthood.

MeSH Terms
Aging/metabolism Animals Centrosome/metabolism Humans Neoplasms/metabolism Stem Cells/cytology,metabolism
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Morrison Sean J
Howard Hughes Medical Institute, Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI, 48109-2216, USA. seanjm@med.umich.edu
Spradling Allan C
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2008.01.038
Email
seanjm@med.umich.edu
Published
2008-02-22
Pages
598-611
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC4505728
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1016/j.cell.2008.01.038 PMC Full Text View journal details
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