Home LiteratureArticle Details
PMID: 17670975 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 27 ·No. 31 ·2007-08-01 ·Pages 8286-96

Young KM, Fogarty M, Kessaris N, Richardson WD

Abstract

We determined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ganglionic eminence (LGE) and the cerebral cortex, contribute multipotent, self-renewing stem cells to the adult SVZ. Descendants of the embryonic LGE and cortex settle in ventral and dorsal aspects of the dorsolateral SVZ, respectively. Both populations contribute new (5-bromo-2'-deoxyuridine-labeled) tyrosine hydroxylase- and calretinin-positive interneurons to the adult olfactory bulb. However, calbindin-positive interneurons in the olfactory glomeruli were generated exclusively by LGE-derived stem cells. Thus, different SVZ stem cells have different embryonic origins, colonize different parts of the SVZ, and generate different neuronal progeny, suggesting that some aspects of embryonic patterning are preserved in the adult SVZ. This could have important implications for the design of endogenous stem cell-based therapies in the future.

MeSH Terms
Animals Cell Differentiation/physiology Cell Movement/physiology Cerebral Ventricles/cytology,embryology Embryonic Development/physiology Mice Mice, Transgenic Neuroepithelial Cells/cytology,physiology Olfactory Bulb/cytology,embryology Stem Cells/cytology,physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Young Kaylene M
Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, United Kingdom.
Fogarty Matthew
Kessaris Nicoletta
Richardson William D
References (46)
46 references, click to expand
  1. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
    Cell. 1999 Jun 11;97(6):703-16 PMID: 10380923
  2. Regeneration of a germinal layer in the adult mammalian brain.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11619-24 PMID: 10500226
  3. Mammalian neural stem cells.
    Science. 2000 Feb 25;287(5457):1433-8 PMID: 10688783
  4. Induction of neurogenesis in the neocortex of adult mice.
    Nature. 2000 Jun 22;405(6789):951-5 PMID: 10879536
  5. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.
    Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13883-8 PMID: 11095732
  6. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain.
    Blood. 2001 Jan 1;97(1):324-6 PMID: 11133778
  7. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus.
    BMC Dev Biol. 2001;1:4 PMID: 11299042
  8. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.
    J Neurosci. 2002 Jan 15;22(2):437-45 PMID: 11784788
  9. Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia.
    J Neurosci. 2002 Apr 15;22(8):3161-73 PMID: 11943818
  10. Reduced anxiety-- and depression-like behaviors in Emx1 homozygous mutant mice.
    Brain Res. 2002 May 24;937(1-2):32-40 PMID: 12020859
  11. Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice.
    Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13211-6 PMID: 12235363
  12. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.
    Neuron. 2002 Dec 19;36(6):1021-34 PMID: 12495619
  13. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin.
    Science. 2003 Jan 3;299(5603):117-20 PMID: 12511652
  14. Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.
    J Neurosci. 2003 Jan 1;23(1):167-74 PMID: 12514213
  15. Neuronal or glial progeny: regional differences in radial glia fate.
    Neuron. 2003 Mar 6;37(5):751-64 PMID: 12628166
  16. Radial glia diversity: a matter of cell fate.
    Glia. 2003 Jul;43(1):37-43 PMID: 12761864
  17. A niche for adult neural stem cells.
    Curr Opin Genet Dev. 2003 Oct;13(5):543-50 PMID: 14550422
  18. Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro.
    Mol Cell Neurosci. 2003 Nov;24(3):741-52 PMID: 14664822
  19. For the long run: maintaining germinal niches in the adult brain.
    Neuron. 2004 Mar 4;41(5):683-6 PMID: 15003168
  20. Disguising adult neural stem cells.
    Curr Opin Neurobiol. 2004 Feb;14(1):125-31 PMID: 15018948
  21. Radial glia serve as neuronal progenitors in all regions of the central nervous system.
    Neuron. 2004 Mar 25;41(6):881-90 PMID: 15046721
  22. Evidence of newly generated neurons in the human olfactory bulb.
    Brain Res Dev Brain Res. 2004 Jul 19;151(1-2):159-68 PMID: 15246702
  23. De novo generation of neuronal cells from the adult mouse brain.
    Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8591-5 PMID: 1528866
  24. Mash1 specifies neurons and oligodendrocytes in the postnatal brain.
    EMBO J. 2004 Nov 10;23(22):4495-505 PMID: 15496983
  25. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.
    Science. 1992 Mar 27;255(5052):1707-10 PMID: 1553558
  26. Radial glia give rise to adult neural stem cells in the subventricular zone.
    Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17528-32 PMID: 15574494
  27. Origin of the neocortical subependymal cells speculated by Emx1 and GAD67 expression.
    Chem Senses. 2005 Jan;30 Suppl 1:i111-2 PMID: 15738064
  28. A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord.
    Development. 2005 Apr;132(8):1951-9 PMID: 15790969
  29. Neuronal fate determinants of adult olfactory bulb neurogenesis.
    Nat Neurosci. 2005 Jul;8(7):865-72 PMID: 15951811
  30. Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.
    J Neurosci. 2005 Jul 27;25(30):6997-7003 PMID: 16049175
  31. The adult mouse hippocampal progenitor is neurogenic but not a stem cell.
    J Neurosci. 2005 Nov 23;25(47):10815-21 PMID: 16306394
  32. Neural progenitor number is regulated by nuclear factor-kappaB p65 and p50 subunit-dependent proliferation rather than cell survival.
    J Neurosci Res. 2006 Jan;83(1):39-49 PMID: 16307445
  33. Subventricular zone neuroblasts emigrate toward cortical lesions.
    J Neuropathol Exp Neurol. 2005 Dec;64(12):1089-100 PMID: 16319719
  34. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.
    Nat Neurosci. 2006 Feb;9(2):173-9 PMID: 16388308
  35. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons.
    Neuron. 2006 Feb 16;49(4):503-16 PMID: 16476661
  36. Adult neurogenesis and functional plasticity in neuronal circuits.
    Nat Rev Neurosci. 2006 Mar;7(3):179-93 PMID: 16495940
  37. Origin of oligodendrocytes in the subventricular zone of the adult brain.
    J Neurosci. 2006 Jul 26;26(30):7907-18 PMID: 16870736
  38. Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.
    J Cell Biol. 2006 Oct 9;175(1):159-68 PMID: 17030986
  39. Generation of distinct types of periglomerular olfactory bulb interneurons during development and in adult mice: implication for intrinsic properties of the subventricular zone progenitor population.
    J Neurosci. 2007 Jan 17;27(3):657-64 PMID: 17234597
  40. Dorsal radial glia generate olfactory bulb interneurons in the postnatal murine brain.
    J Neurosci. 2007 Apr 18;27(16):4297-302 PMID: 17442813
  41. p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells.
    J Neurosci. 2007 May 9;27(19):5146-55 PMID: 17494700
  42. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb.
    Neurosci Res. 1995 Aug;23(1):73-88 PMID: 7501303
  43. Divergent lineages for oligodendrocytes and astrocytes originating in the neonatal forebrain subventricular zone.
    Glia. 1994 Jul;11(3):211-26 PMID: 7960027
  44. Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain.
    Neuron. 1993 Feb;10(2):201-12 PMID: 8439409
  45. Olfactory bulb development is altered in small-eye (Sey) mice.
    J Comp Neurol. 1998 Dec 21;402(3):402-18 PMID: 9853907
  46. Proliferation, migration and differentiation of neuronal progenitor cells in the adult mouse subventricular zone surgically separated from its olfactory bulb.
    Eur J Neurosci. 1998 Dec;10(12):3853-68 PMID: 9875362
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0476-07.2007
Published
2007-08-01
Pages
8286-96
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6331046
Subset
IM
Grants
Wellcome Trust · United Kingdom
Medical Research Council · G0501173 · United Kingdom
Medical Research Council · G0800575 · United Kingdom
Medical Research Council · G9708005 · United Kingdom
External Links
PubMed source DOI: 10.1523/JNEUROSCI.0476-07.2007 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2