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PMID: 18268012 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Snu56p is required for Mer1p-activated meiotic splicing.

Molecular and cellular biology ·Vol. 28 ·No. 8 ·2008-04-00 ·Pages 2497-508

Balzer RJ, Henry MF

Abstract

Alternative or regulated splicing can be applied to genes that are transcribed but whose products may be deleterious or unnecessary to the cell. In the yeast Saccharomyces cerevisiae, positive splicing regulation occurs during meiosis in which diploid cells divide to form haploid gametes. The Mer1 protein recruits the U1 snRNP to specific pre-mRNAs, permitting spliceosomal assembly and splicing. The mature transcripts are required for meiotic progression and, subsequently, sporulation. We have identified a novel allele (snu56-2) of the essential U1 snRNP protein Snu56p that exhibits a sporulation defect. Using a CUP1 reporter assay and reverse transcriptase PCR, we demonstrate that this allele specifically impairs Mer1p-activated splicing. This is not a reflection of a generally deficient spliceosome, as these cells splice vegetative transcripts efficiently. Furthermore, Snu56p depletion in vivo does not significantly impact mitotic splicing. Thus, its splicing function appears to be limited to Mer1p-activated meiosis-specific splicing. Two-hybrid studies indicate that Snu56p interacts with the other two U1 snRNP factors (Mer1p and Nam8p) required for this process. Interestingly, these two proteins do not interact, suggesting that Snu56p links pre-mRNA-bound Mer1p to Nam8p in the U1 snRNP. This work demonstrates that the Snu56 protein is required for splicing only during meiosis.

MeSH Terms
Alleles Diploidy Gene Deletion Gene Expression Regulation, Fungal Homozygote Meiosis/genetics Protein Binding Protein-Arginine N-Methyltransferases/genetics,metabolism RNA Splicing/genetics RNA-Binding Proteins/genetics,metabolism Repressor Proteins/genetics,metabolism Ribonucleoprotein, U1 Small Nuclear/genetics,metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins/genetics,metabolism Sensitivity and Specificity Two-Hybrid System Techniques
Chemicals
MER1 protein, S cerevisiae RNA-Binding Proteins Repressor Proteins Ribonucleoprotein, U1 Small Nuclear Saccharomyces cerevisiae Proteins Snu56 protein, S cerevisiae HMT1 protein, S cerevisiae Protein-Arginine N-Methyltransferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Balzer Richard J
Department of Molecular Biology, UMNDJ-SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA. henrymf@umdnj.edu
Henry Michael F
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
1098-5549
Published
2008-04-00
Epub
2008-00-11
Pages
2497-508
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC2293118
Subset
IM
Grants
NIGMS NIH HHS · R01 GM058493 · United States
NIGMS NIH HHS · GM58493 · United States
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