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PMID: 18256699 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

3' end mRNA processing: molecular mechanisms and implications for health and disease.

The EMBO journal ·Vol. 27 ·No. 3 ·2008-02-06 ·Pages 482-98

Danckwardt S, Hentze MW, Kulozik AE

Abstract

Recent advances in the understanding of the molecular mechanism of mRNA 3' end processing have uncovered a previously unanticipated integrated network of transcriptional and RNA-processing mechanisms. A variety of human diseases impressively reflect the importance of the precision of the complex 3' end-processing machinery and gene specific deregulation of 3' end processing can result from mutations of RNA sequence elements that bind key specific processing factors. Interestingly, more general deregulation of 3' end processing can be caused either by mutations of these processing factors or by the disturbance of the well-coordinated equilibrium between these factors. From a medical perspective, both loss of function and gain of function can be functionally relevant, and an increasing number of different disease entities exemplifies that inappropriate 3' end formation of human mRNAs can have a tremendous impact on health and disease. Here, we review the mechanistic hallmarks of mRNA 3' end processing, highlight the medical relevance of deregulation of this important step of mRNA maturation and illustrate the implications for diagnostic and therapeutic strategies.

MeSH Terms
Animals Humans Immunity/genetics Inflammation/genetics,metabolism,pathology Mutation Neoplasms/chemistry,genetics,metabolism,pathology RNA 3' End Processing/physiology RNA, Messenger/biosynthesis,chemistry,genetics,physiology Transcription, Genetic/physiology
Chemicals
RNA, Messenger
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Danckwardt Sven
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.
Hentze Matthias W
Kulozik Andreas E
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.1038/sj.emboj.7601932
Published
2008-02-06
Pages
482-98
Language
English
Region
England
NLM ID
8208664
PMCID
PMC2241648
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.emboj.7601932 PMC Full Text View journal details
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