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PMID: 18250311 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Evolution of polyketide synthases in bacteria.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 105 ·No. 12 ·2008-03-25 ·Pages 4595-600

Ridley CP, Lee HY, Khosla C

Abstract

The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in generating the next generation of polyketide antibiotics. Here, we examine phylogenetic and structural evidence to glean answers to two general questions regarding PKS evolution. How did the exceptionally diverse chemistry of present-day PKSs evolve? And what are the take-home messages for the biosynthetic engineer?

MeSH Terms
Bacteria/enzymology Base Sequence Evolution, Molecular Gene Transfer, Horizontal Macrolides/chemistry Molecular Sequence Data Multigene Family Phylogeny Polyketide Synthases/chemistry,genetics Protein Structure, Secondary Protein Structure, Tertiary Recombination, Genetic
Chemicals
Macrolides Polyketide Synthases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ridley Christian P
Departments of Chemistry, Chemical Engineering, and Biochemistry, Stanford University, Stanford, CA 94305, USA.
Lee Ho Young
Khosla Chaitan
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.0710107105
Published
2008-03-25
Epub
2008-00-04
Pages
4595-600
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2290765
Subset
IM
Grants
NCI NIH HHS · R01 CA066736 · United States
NCI NIH HHS · R01 CA077248 · United States
NCI NIH HHS · CA 66736 · United States
NCI NIH HHS · CA 77248 · United States
External Links
PubMed source DOI: 10.1073/pnas.0710107105 PMC Full Text View journal details
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