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PMID: 18226917 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Elevated levels of soluble ST2 protein in dengue virus infected patients.

Cytokine ·Vol. 41 ·No. 2 ·2008-02-00 ·Pages 114-20

Becerra A, Warke RV, de Bosch N, Rothman AL, Bosch I

Abstract

Levels of the soluble form of the interleukin-1 receptor-like 1 protein (IL-1RL-1/ST2) are elevated in the serum of patients with diseases characterized by an inflammatory response. The objective of this study was to determine the concentration of soluble ST2 (sST2) in dengue infected patients during the course of the disease. Twenty-four patients with confirmed dengue infection, classified as dengue fever, and 11 patients with other febrile illness (OFI) were evaluated. Levels of sST2 in serum and laboratory variables usually altered during dengue infections were measured. Dengue infected patients had higher serum sST2 levels than OFI at the end of the febrile stage and at defervescence (p=0.0088 and p=0.0004, respectively). Patients with secondary dengue infections had higher serum sST2 levels compared with patients with primary dengue infections (p=0.047 at last day of fever and p=0.030 at defervescence). Furthermore, in dengue infected patients, we found a significant negative correlation of sST2 with platelet and WBC counts, and positive correlation with thrombin time and transaminases activity. We suggest that sST2 could be a potential marker of dengue infection, could be associated with severity or could play a role in the immune response in secondary dengue virus infection.

MeSH Terms
Adolescent Adult Child Dengue/blood Female Humans Interleukin-1 Receptor-Like 1 Protein Male Middle Aged Receptors, Cell Surface/blood
Chemicals
IL1RL1 protein, human Interleukin-1 Receptor-Like 1 Protein Receptors, Cell Surface
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Becerra Aniuska
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Warke Rajas V
de Bosch Norma
Rothman Alan L
Bosch Irene
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Article Info
Journal
Cytokine
Abbr.
Cytokine
ISSN
1096-0023
DOI
10.1016/j.cyto.2007.11.001
Published
2008-02-00
Epub
2008-00-28
Pages
114-20
Language
English
Region
England
NLM ID
9005353
PMCID
PMC2276732
Subset
IM
Grants
NIAID NIH HHS · U01 AI045440-05 · United States
NIAID NIH HHS · U01 AI045440 · United States
NIAID NIH HHS · U01 AI45440 · United States
NIAID NIH HHS · U01 AI070484 · United States
NIAID NIH HHS · U01 AI070484-02 · United States
External Links
PubMed source DOI: 10.1016/j.cyto.2007.11.001 PMC Full Text View journal details
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