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PMID: 1819728 Published · ppublish English Journal Article Review

Significance of platelet-activating factor in mesenteric ischemia-reperfusion.

Lipids ·Vol. 26 ·No. 12 ·1991-12-00 ·Pages 1336-9

Filep J, Braquet P, Mózes T

Abstract

Reperfusion of the ischemic mesenterium is frequently followed by acute circulatory collapse. This review focuses on the possible role of platelet-activating factor (PAF) in ischemia-induced damage. It provides evidence that (i) PAF concentrations are elevated in the mesenteric circulation following temporary ischemia; (ii) administration of exogenous PAF into the superior mesenteric vein mimics many events observed during reperfusion; and (iii) pretreatment of the experimental animals with specific PAF receptor antagonists prevent the circulatory collapse. These findings suggest that PAF may play an important role in the development of circulatory collapse caused by mesenteric ischemia-reperfusion.

MeSH Terms
Animals Blood Pressure/drug effects Humans Ischemia/physiopathology Platelet Activating Factor/pharmacology,physiology,toxicity Reperfusion Splanchnic Circulation
Chemicals
Platelet Activating Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Filep J
Department of Pathophysiology, Semmelweis University Medical School, Budapest, Hungary.
Braquet P
Mózes T
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43 references, click to expand
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Article Info
Journal
Lipids
Abbr.
Lipids
ISSN
0024-4201
DOI
10.1007/BF02536561
Published
1991-12-00
Pages
1336-9
Language
English
Region
United States
NLM ID
0060450
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02536561 View journal details
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