Home LiteratureArticle Details
PMID: 4118412 Published · ppublish English Journal Article

Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor.

The Journal of experimental medicine ·Vol. 136 ·No. 6 ·1972-12-01 ·Pages 1356-77

Benveniste J, Henson PM, Cochrane CG

Abstract

We have studied the leukocyte-dependent mechanism of histamine release (LDHR) from rabbit platelets, a complement-independent mechanism which has been implicated in the deposition of immune complexes in acute serum sickness of rabbits. It was found by chromatography and passive transfer of serum from immunized rabbits that the antibody responsible for the LDHR was of IgE type. By electron microscope study of the reaction, the leukocyte involved in agglutination of platelets and release of their histamine content was identified as the basophil. Upon addition of antigen, basophils sensitized with IgE degranulated, released their histamine content and a platelet-activating factor (PAF) that caused aggregation of platelets and release of their histamine. Conditions of preparing and preserving PAF activity and some properties of this factor have been elucidated. LDHR must, therefore, be considered as an immediate hypersensitivity-type mechanism which may link allergic reactions with immunologic disease associated with severe structural injury.

MeSH Terms
Animals Antibodies Basophils/immunology Blood Platelets/metabolism Chromatography, DEAE-Cellulose Complement System Proteins Histamine Release Immune Sera Immunity, Active Immunity, Maternally-Acquired Immunoelectrophoresis Immunoglobulin E Leukocytes/immunology Microscopy, Electron Platelet Adhesiveness Rabbits Serum Albumin, Bovine
Chemicals
Antibodies Immune Sera Serum Albumin, Bovine Immunoglobulin E Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Benveniste J
Henson P M
Cochrane C G
References (29)
29 references, click to expand
  1. Colorimetric investigation of the uptake of an intravenously injected protein (horseradish peroxidase) by rat kidney and effects of competition by egg white.
    J Cell Biol. 1962 Feb;12:231-46 PMID: 13917690
  2. The passage of colloidal particles across the dermal capillary wall under the influence of histamine.
    Q J Exp Physiol Cogn Med Sci. 1959 Jan;44(1):51-66 PMID: 13624013
  3. The localization of circulating immune complexes in experimental serum sickness. The role of vasoactive amines and hydrodynamic forces.
    J Exp Med. 1968 Jan 1;127(1):119-36 PMID: 4864670
  4. Antigen induced histamine release from platelets of rabbits producing homologous PCA antibody.
    Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1245-7 PMID: 4162045
  5. Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction.
    Prog Allergy. 1958;5:459-508 PMID: 13579002
  6. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.
    J Histochem Cytochem. 1966 Apr;14(4):291-302 PMID: 5962951
  7. In vitro histamine release from blood cellular elements of rabbits infected with Schistosoma mansoni.
    Proc Soc Exp Biol Med. 1968 Feb;127(2):601-6 PMID: 4171376
  8. Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement.
    J Exp Med. 1969 Jan 1;129(1):167-84 PMID: 4178112
  9. Localization of colloidal substances in vascular endothelium: a mechanism of tissue damage. I. Factors causing the pathologic deposition of colloidal carbon.
    Am J Pathol. 1959 Jan-Feb;35(1):75-91 PMID: 13617411
  10. Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets.
    J Exp Med. 1971 Mar 1;133(3):554-71 PMID: 4106804
  11. Leukocyte preparations from human blood: evaluation of their morphologic and metabolic state.
    J Lab Clin Med. 1962 May;59:779-91 PMID: 13891473
  12. Mechanisms of reaginic hypersensitivity: a review.
    Clin Allergy. 1971 Mar;1(1):9-24 PMID: 4115167
  13. STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. I. STRUCTURAL STUDIES.
    J Exp Med. 1963 Oct 1;118:489-502 PMID: 14067901
  14. Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.
    J Immunol. 1970 Dec;105(6):1459-67 PMID: 4098503
  15. Interaction of rabbit platelets and leukocytes in the release of histamine. Electron microscopic observations.
    Am J Pathol. 1971 Apr;63(1):85-98 PMID: 4101057
  16. Slow reacting substance of anaphylaxis.
    Adv Immunol. 1969;10:105-44 PMID: 4188319
  17. Rabbit homocytotropic antibody. A unique rabbit immunoglobulin analogous to human IgE.
    J Exp Med. 1969 Oct 1;130(4):907-29 PMID: 4186446
  18. In vivo passive sensitization of normal rabbit leukocytes with sera demonstrating homocytotropic antibody activity.
    Int Arch Allergy Appl Immunol. 1971;41(5):754-64 PMID: 4130678
  19. The relationships between serum complement activity and the development of allergic lesions in rabbits.
    J Exp Med. 1961 Nov 1;114:633-46 PMID: 14491800
  20. The nature of the reaction of antigen with lymphocytes from rabbits infected with Schistosoma mansoni on the release of histamine from rabbit platelets.
    J Immunol. 1970 May;104(5):1124-31 PMID: 4193198
  21. Destruction of rabbit platelets in the allergic response of sensitized leukocytes. II. Evidence for basophil involvement.
    J Immunol. 1971 May;106(5):1252-9 PMID: 4102402
  22. Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate.
    J Immunol. 1971 May;106(5):1244-51 PMID: 4102401
  23. Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen.
    J Exp Med. 1970 Feb;131(2):287-306 PMID: 5419850
  24. Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: an electron microscopic study.
    J Biophys Biochem Cytol. 1961 Dec;11:571-605 PMID: 14468626
  25. Rabbit anaphylactic antibody.
    J Exp Med. 1966 May 1;123(5):935-50 PMID: 5938818
  26. Studies on circulating immune complexes. 3. Factors governing the ability of circulating complexes to localize in blood vessels.
    J Exp Med. 1968 Jan 1;127(1):137-54 PMID: 4169437
  27. STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. II. PATHOGENETIC AND PHARMACODYNAMIC STUDIES.
    J Exp Med. 1963 Oct 1;118:503-13 PMID: 14067902
  28. Mechanisms of release of constituents from rabbit platelets by antigen-antibody complexes and complement. II. Interaction of platelets with neutrophils.
    J Immunol. 1970 Aug;105(2):490-501 PMID: 4393563
  29. PLATELET SEQUESTRATION IN MAN. I. METHODS.
    J Clin Invest. 1964 May;43:843-55 PMID: 14169513
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.136.6.1356
Published
1972-12-01
Pages
1356-77
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139324
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.136.6.1356 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2