The nature of the virus receptors of red cells; partial purification of the virus agglutination inhibitor in human plasma.

The Journal of experimental medicine ·Vol. 89 ·No. 2 ·1949-02-00 ·Pages 223-32

HIRST GK

Abstract

A substance (VHI) exists in human plasma which inhibits the agglutination of red cells by influenza virus and is distinct from influenza antibody. When plasma is fractionated by alcohol in the cold the VHI comes out mainly with a mixture of lipid-free alpha and beta globulins (fraction IV-4). On further fractionation the activity comes out with a fraction consisting mainly of beta(1) globulin (fraction IV-7). Boiling fraction IV-4 or IV-7 after considerable dilution brings about a large increase in the amount of VHI, much more than can be detected in the original plasma. A similar VHI has been extracted from the ghosts of fowl red cells.

Keywords

VIRUSES

MeSH Terms

Agglutination Antibodies, Viral Erythrocytes Humans Receptors, Virus Viruses

Chemicals

Antibodies, Viral Receptors, Virus

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

HIRST G K

References (10)

10 references, click to expand

Seromucoid and the bound carbohydrate of the serum proteins.
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The nature of the virus receptors of red cells; evidence on the chemical nature of the virus receptors of red cells and of the existence of a closely analogous substance in normal serum.
J Exp Med. 1948 Apr 1;87(4):301-14 PMID: 18904216
PREPARATION FROM HUMAN RED CELLS OF A SUBSTANCE INHIBITING VIRUS HEMAGGLUTINATION.
J Exp Med. 1948 Jan 1;87(1):1-9 PMID: 19871694
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : II. PROPERTIES OF THE BLOOD GROUP A SUBSTANCE FROM POOLS OF HOO STOMACHS AND OF SPECIFIC PRECIPITATES COMPOSED OF "A" SUBSTANCE AND HOMOLOGOUS HUMAN ANTIBODY.
J Exp Med. 1946 May 31;83(6):477-84 PMID: 19871544
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : I. ESTIMATION OF A AND B ISOANTIBODIES IN HUMAN SERUM BY THE QUANTITATIVE PRECIPITIN METHOD.
J Exp Med. 1945 Sep 1;82(3):207-15 PMID: 19871495
Studies in immunochemistry: 7. The isolation from hog gastric mucin of the polysaccharide-amino acid complex possessing blood group A specificity.
Biochem J. 1943;37(5):640-51 PMID: 16747710
The nature of the virus receptors of red cells; the effect of partial heat inactivation of influenza virus on the destruction of red cell receptors and the use of inactivated virus in the measurement of serum inhibitor.
J Exp Med. 1948 Apr 1;87(4):315-28 PMID: 18904217
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : III. PROPERTIES OF PURIFIED BLOOD GROUP A SUBSTANCES FROM INDIVIDUAL HOG STOMACH LININGS.
J Exp Med. 1946 May 31;83(6):485-97 PMID: 19871545
ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS.
J Exp Med. 1942 Aug 1;76(2):195-209 PMID: 19871229
The inactivation of biologically active proteins, and the virus of western equine encephalomyelitis by periodic acid.
J Exp Med. 1948 May 1;87(5):445-55 PMID: 18912894

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.89.2.223

Published

1949-02-00

Pages

223-32

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2135861

Subset

External Links

PubMed source DOI: 10.1084/jem.89.2.223 PMC Full Text View journal details

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The nature of the virus receptors of red cells; partial purification of the virus agglutination inhibitor in human plasma.

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