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PMID: 18042690 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma.

Journal of clinical pathology ·Vol. 60 ·No. 12 ·2007-12-00 ·Pages 1342-9

Kapatai G, Murray P

Abstract

Although the morphology of the pathognomonic Reed-Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of HL in some cases. This review summarises current knowledge of the pathogenesis of HL with particular emphasis on the association with EBV.

MeSH Terms
Cell Transformation, Neoplastic/genetics Cell Transformation, Viral/genetics Epstein-Barr Virus Infections/complications Genes, Viral Herpesvirus 4, Human/genetics,isolation & purification Hodgkin Disease/genetics,therapy,virology Humans Immunotherapy/methods Reed-Sternberg Cells/virology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kapatai G
The Cancer Research UK Institute for Cancer Studies, Medical School, University of Birmingham, Birmingham, UK.
Murray P
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
1472-4146
DOI
10.1136/jcp.2007.050146
Published
2007-12-00
Pages
1342-9
Language
English
Region
England
NLM ID
0376601
PMCID
PMC2095570
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.2007.050146 PMC Full Text View journal details
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