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PMID: 18023996 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

E2F-associated chromatin modifiers and cell cycle control.

Current opinion in cell biology ·Vol. 19 ·No. 6 ·2007-12-00 ·Pages 658-62

Blais A, Dynlacht BD

Abstract

The E2F family of proteins was identified on the basis of its role in promoting the G0 to S phase transition. Research over the past several years has unveiled considerable complexity within the family, with numerous studies pointing to delegation of function for distinct family members. More recent studies highlighted in this review have expanded this picture, suggesting ways in which E2F target gene expression is refined during cell cycle progression by facilitating the acquisition of promoter-specific histone modifications. E2F associated co-activators promote activating histone marks while recruitment of co-repressors associated with E2Fs and the pRB family leads to accretion of inhibitory histone modifications that provoke chromatin compaction.

MeSH Terms
Cell Cycle/physiology Cell Cycle Proteins/metabolism Chromatin Assembly and Disassembly E2F Transcription Factors/physiology Histones/metabolism Humans
Chemicals
Cell Cycle Proteins E2F Transcription Factors Histones
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Blais Alexandre
Ottawa Institute of Systems Biology and Biochemistry, Microbiology and Immunology Department, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.
Dynlacht Brian D
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/j.ceb.2007.10.003
Published
2007-12-00
Epub
2007-00-19
Pages
658-62
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3586187
Subset
IM
Grants
NCI NIH HHS · R01 CA077245 · United States
NCI NIH HHS · R01 CA077245-10 · United States
NCI NIH HHS · CA77245-06 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2007.10.003 PMC Full Text View journal details
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