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PMID: 17928949 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

FTO polymorphisms in oceanic populations.

Journal of human genetics ·Vol. 52 ·No. 12 ·2007-00-00 ·Pages 1031-1035

Ohashi J, Naka I, Kimura R, Natsuhara K, Yamauchi T, Furusawa T, Nakazawa M, Ataka Y, Patarapotikul J, Nuchnoi P, Tokunaga K, Ishida T, Inaoka T, Matsumura Y, Ohtsuka R

Abstract

It has been suggested that Neel's "thrifty genotype" model may account for high body weights in some Oceanic populations, which presumably arose in modern times. In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity. In this study, we investigated the population frequencies of these variants in six Oceanic populations (Melanesians, Micronesians, and Polynesians) and tested for an association with BMI. Unlike European populations, the Oceanic populations displayed no significant association between the FTO polymorphisms and BMI. These variants were in strong linkage disequilibrium. The population frequencies ranged between 4.2 and 30.3% in the six Oceanic populations, and were similar to those in southeast and east Asian populations. Our study of the FTO polymorphisms has generated no evidence to support the thrifty genotype hypothesis for Oceanic populations.

MeSH Terms

Adipose Tissue Alpha-Ketoglutarate-Dependent Dioxygenase FTO Blacks/genetics Body Mass Index Genetics, Population Humans Linkage Disequilibrium Models, Genetic Obesity/genetics Pacific Islands Polymorphism, Genetic Proteins/genetics Whites/genetics

Chemicals

Proteins Alpha-Ketoglutarate-Dependent Dioxygenase FTO FTO protein, human

Authors & Affiliations

15 authors, click to expand affiliations / ORCID

Ohashi Jun

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. juno-tky@umin.ac.jp.

Naka Izumi

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Kimura Ryosuke

Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa, Japan.

Natsuhara Kazumi

School of Nursing, Fukuoka Prefectural University, Fukuoka, Japan.

Yamauchi Taro

Department of Health Sciences, Hokkaido University School of Medicine, Hokkaido, Japan.

Furusawa Takuro

ASNET Promotion Office, Division for International Relations, The University of Tokyo, Tokyo, Japan.

Nakazawa Minato

Department of Public Health, Graduate School of Medicine, Gunma University, Gunma, Japan.

Ataka Yuji

School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan.

Patarapotikul Jintana

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Nuchnoi Pornlada

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Tokunaga Katsushi

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Ishida Takafumi

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Inaoka Tsukasa

Department of Environmental Sociology, Faculty of Agriculture, Saga University, Saga, Japan.

Matsumura Yasuhiro

Information Center, National Institute of Health and Nutrition, Tokyo, Japan.

Ohtsuka Ryutaro

National Institute for Environmental Studies, Ibaraki, Japan.

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12 references, click to expand

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Article Info

Journal

Journal of human genetics

Abbr.

J Hum Genet

ISSN

1434-5161

DOI

10.1007/s10038-007-0198-2

juno-tky@umin.ac.jp

Published

2007-00-00

Epub

2007-00-11

Pages

1031-1035

Language

English

Region

England

NLM ID

9808008

Subset

External Links

PubMed source DOI: 10.1007/s10038-007-0198-2 View journal details

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FTO polymorphisms in oceanic populations.

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