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PMID: 17906672 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The inner nuclear envelope as a transcription factor resting place.

EMBO reports ·Vol. 8 ·No. 10 ·2007-10-00 ·Pages 914-9

Heessen S, Fornerod M

Abstract

Just as people head to the beaches for a well-deserved rest, accumulating evidence suggests that transcription factors take similar 'vacations' at the nuclear envelope. Recent studies indicate that the periphery of the nucleus provides a platform for sequestering transcription factors away from chromatin. Several transcriptional regulators, operating in different signal-transduction pathways, have been found to interact physically with components of the inner nuclear membrane. In general, this association seems to restrict access to their target genes and limit their transactivation or transrepression abilities. The mechanisms of inner nuclear membrane association are diverse, and include regulated associations with the nuclear lamina and integral membrane proteins. Together, these findings indicate that the inside of the nuclear envelope functions as a resting place for transcription factors and suggest a more direct role for the nuclear envelope in gene regulation than previously anticipated.

MeSH Terms
Animals Humans Lamins/metabolism Models, Biological Nuclear Envelope/metabolism Nuclear Lamina/metabolism Nuclear Proteins/metabolism Signal Transduction Transcription Factors/metabolism
Chemicals
Lamins Nuclear Proteins Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Heessen Stijn
Department of Tumour Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Fornerod Maarten
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.7401075
Published
2007-10-00
Pages
914-9
Language
English
Region
England
NLM ID
100963049
PMCID
PMC2002563
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.7401075 PMC Full Text View journal details
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