Rhinovirus multistranded RNA: dependence of the replicative form on the presence of actinomycin D.

Journal of virology ·Vol. 18 ·No. 3 ·1976-06-00 ·Pages 926-32

Macnaughton MR, Cooper JA, Dimmock NJ

Abstract

The multistranded and double-stranded RNAs synthesized in HeLa cells infected with rhinovirus in the presence and in the absence of actinomycin D have been characterized by polyacrylamide gel electrophoresis and hybridization studies. The replicative form is only found in infected cells treated with actinomycin D, whereas the replicative intermediate is found in both the presence and the absence of the drug. The significance of these results is discussed.

MeSH Terms

Dactinomycin/pharmacology HeLa Cells RNA, Viral/analysis,biosynthesis Rhinovirus/analysis,growth & development,metabolism Virus Replication/drug effects

Chemicals

RNA, Viral Dactinomycin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Macnaughton M R

Cooper J A

Dimmock N J

References (30)

30 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.18.3.926-932.1976

Published

1976-06-00

Pages

926-32

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC354792

Subset

External Links

PubMed source DOI: 10.1128/JVI.18.3.926-932.1976 PMC Full Text View journal details

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Rhinovirus multistranded RNA: dependence of the replicative form on the presence of actinomycin D.

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