Home LiteratureArticle Details
PMID: 178595 Published · ppublish English Journal Article

Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression.

Infection and immunity ·Vol. 13 ·No. 3 ·1976-03-00 ·Pages 844-54

Haller O, Arnheiter H, Lindenmann J

Abstract

Mice carrying the gene Mx were resistant to the lethal action of a hepatotropic line of avian influenza A virus. In resistant animals, foci of liver necrosis were self-limiting, and maximal virus titers reached were much below those in susceptible animals. Resistance could not be abrogated by immunosuppressive treatment with cyclophosphamide, methotrexate, or procarbazine, although such treatment prevented cellular infiltration at sites of virus replication and appeared to delay virus clearance. Silica and thorium dioxide, thought to inhibit macrophage function, likewise failed to abolish resistance. Regenerating liver tissue did not support more extensive virus replication than did intact adult liver.

MeSH Terms
Animals Antigens, Viral/analysis Cyclophosphamide/pharmacology Hepatectomy Immunosuppression Therapy Liver/microbiology,pathology Liver Regeneration Methotrexate/pharmacology Mice Mice, Inbred A Mice, Inbred C57BL Mice, Inbred ICR Mononuclear Phagocyte System/microbiology Orthomyxoviridae/growth & development,pathogenicity Orthomyxoviridae Infections/genetics,prevention & control Procarbazine/pharmacology Silicon Dioxide/pharmacology Thorium Dioxide/pharmacology
Chemicals
Antigens, Viral Procarbazine Silicon Dioxide Cyclophosphamide Thorium Dioxide Methotrexate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Haller O
Arnheiter H
Lindenmann J
References (30)
30 references, click to expand
  1. Regeneration of mouse liver after partial hepatectomy.
    Cancer Res. 1953 Jan;13(1):80-5 PMID: 13032955
  2. Cytological changes in regenerating mouse liver.
    Cancer Res. 1953 Jan;13(1):86-92 PMID: 13032956
  3. Sparing effect of A-methopterin and guanazolo in mice infected with virus of lymphocytic choriomeningitis.
    Virology. 1956 Aug;2(4):511-6 PMID: 13352776
  4. THE RESISTANCE OF A2G MICE TO MYXOVIRUSES.
    J Immunol. 1963 Jun;90:942-51 PMID: 14050204
  5. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES.
    Bacteriol Rev. 1964 Mar;28:30-71 PMID: 14127970
  6. INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE.
    Proc Soc Exp Biol Med. 1964 Jun;116:506-9 PMID: 14193387
  7. Effect of immunosuppression on the genetic resistance of A2G mice to neurovirulent influenza virus.
    Infect Immun. 1975 Mar;11(3):576-87 PMID: 163800
  8. Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria.
    Transplant Rev. 1974;19(0):3-55 PMID: 4135465
  9. An examination of the cytotoxic effects of silica on macrophages.
    J Exp Med. 1966 Aug 1;124(2):141-54 PMID: 4288309
  10. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.
    J Immunol. 1970 May;104(5):1155-9 PMID: 4315460
  11. Host defenses against viral disease.
    N Engl J Med. 1974 Feb 7;290(6):323-9 PMID: 4358448
  12. Intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. 3. Suppressive effect of cyclophosphamide on the establishment and duration of the intestinal resistance.
    Jpn J Microbiol. 1973 Nov;17(6):503-11 PMID: 4365101
  13. Cyclophosphamide-potentiated West Nile viral encephalitis: relative influence of cellular and humoral factors.
    J Infect Dis. 1974 Dec;130(6):634-41 PMID: 4372273
  14. Treatment of canine graft-versus-host disease with methotrexate and cyclo-phosphamide following bone marrow transplantation from histoincompatible donors.
    Transplantation. 1970 Aug;10(2):165-72 PMID: 4393683
  15. The effect of amethopterin on the immune response.
    Ann N Y Acad Sci. 1971 Nov 30;186:467-74 PMID: 4399933
  16. Athymic (nude) mice express gene for myxovirus resistance.
    Nature. 1974 Aug 23;250(5468):679-80 PMID: 4546732
  17. Immunosuppression by alkylating agents--tolerance induction.
    Transplant Proc. 1973 Sep;5(3):1221-6 PMID: 4580720
  18. Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice.
    J Infect Dis. 1974 Mar;129(3):248-56 PMID: 4593241
  19. Viral infection and host defense.
    Science. 1974 Dec 27;186(4170):1172-8 PMID: 4610750
  20. Immunosuppression by procarbazine. I. Sites of action of the drug and effect on adjuvant arthritis and circulating antibody responses.
    Cell Immunol. 1972 Feb;3(2):198-212 PMID: 4622095
  21. Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (HON1) influenza virus.
    J Virol. 1973 Feb;11(2):272-8 PMID: 4688703
  22. Effects of immunosuppression on coxsackie B-3 virus infection in mice, and passive protection by circulating antibody.
    J Gen Virol. 1973 Jun;19(3):339-51 PMID: 4723533
  23. A comparative study of the action of cyclophosphamide and procarbazine on the antibody production in mice.
    Clin Exp Immunol. 1973 Oct;15(2):271-80 PMID: 4762019
  24. Immunosuppressive drugs.
    Pharmacol Rev. 1970 Jun;22(2):189-247 PMID: 4914001
  25. Mechanism of recovery from systemic vaccinia virus infection. I. The effects of cyclophosphamide.
    J Exp Med. 1972 Aug 1;136(2):277-90 PMID: 5043413
  26. Effects of thorotrast on humoral antibody, viral multiplication, and interferon during infection with St. Louis encephalitis virus in mice.
    J Infect Dis. 1971 Mar;123(3):297-300 PMID: 5111885
  27. Effect of methylhydrazine derivatives on the survival of second-set skin homografts.
    Nature. 1966 Aug 6;211(5049):638-9 PMID: 5338821
  28. Potentiation of experimental arbovirus encephalitis by immunosuppressive doses of cyclophosphamide.
    Nature. 1968 Oct 26;220(5165):399-401 PMID: 5684888
  29. The effect of cyclophosphamide treatment on experimental arbovirus infections.
    Am J Epidemiol. 1969 Jul;90(1):62-8 PMID: 5798370
  30. [On the problem of natural antiviral immunity. The hereditary character and mechanism of resistance of mice of the A2G line to influenza virus].
    Vopr Virusol. 1966 Jul-Aug;11(4):398-402 PMID: 6003691
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.13.3.844-854.1976
Published
1976-03-00
Pages
844-54
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC420687
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.13.3.844-854.1976 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2