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PMID: 17804111 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Hyaluronan-dependent pericellular matrix.

Advanced drug delivery reviews ·Vol. 59 ·No. 13 ·2007-11-10 ·Pages 1351-65

Evanko SP, Tammi MI, Tammi RH, Wight TN

Abstract

Hyaluronan is a multifunctional glycosaminoglycan that forms the structural basis of the pericellular matrix. Hyaluronan is extruded directly through the plasma membrane by one of three hyaluronan synthases and anchored to the cell surface by the synthase or cell surface receptors such as CD44 or RHAMM. Aggregating proteoglycans and other hyaluronan-binding proteins, contribute to the material and biological properties of the matrix and regulate cell and tissue function. The pericellular matrix plays multiple complex roles in cell adhesion/de-adhesion, and cell shape changes associated with proliferation and locomotion. Time-lapse studies show that pericellular matrix formation facilitates cell detachment and mitotic cell rounding. Hyaluronan crosslinking occurs through various proteins, such as tenascin, TSG-6, inter-alpha-trypsin inhibitor, pentraxin and TSP-1. This creates higher order levels of structured hyaluronan that may regulate inflammation and other biological processes. Microvillous or filopodial membrane protrusions are created by active hyaluronan synthesis, and form the scaffold of hyaluronan coats in certain cells. The importance of the pericellular matrix in cellular mechanotransduction and the response to mechanical strain are also discussed.

MeSH Terms
Animals Cell Adhesion/physiology Cell Membrane/physiology,ultrastructure Cell Movement/physiology Cell Proliferation Cell-Matrix Junctions/physiology,ultrastructure Cross-Linking Reagents/pharmacology Extracellular Matrix/physiology,ultrastructure Humans Hyaluronic Acid/physiology Signal Transduction/physiology
Chemicals
Cross-Linking Reagents Hyaluronic Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Evanko Stephen P
The Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101, USA.
Tammi Markku I
Tammi Raija H
Wight Thomas N
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Article Info
Journal
Advanced drug delivery reviews
Abbr.
Adv Drug Deliv Rev
ISSN
0169-409X
DOI
10.1016/j.addr.2007.08.008
Published
2007-11-10
Epub
2007-00-14
Pages
1351-65
Language
English
Region
Netherlands
NLM ID
8710523
PMCID
PMC2174428
Subset
IM
Grants
NHLBI NIH HHS · P01 HL018645 · United States
NHLBI NIH HHS · P01 HL018645-310023 · United States
NHLBI NIH HHS · P01 HL018645-31 · United States
External Links
PubMed source DOI: 10.1016/j.addr.2007.08.008 PMC Full Text View journal details
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