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PMID: 177973 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Deficiency in histone acetylation in nontransforming host range mutants of polyoma virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 4 ·1976-04-00 ·Pages 1092-6

Schaffhausen BS, Benjamin TL

Abstract

Histones H3 and H4 derived from transforming wild-type polyoma and simian virus 40 particles show extensive acetylation compared to the histones of the host cells. The same histone fractions derived from nontransforming host range mutants of polyoma virus fail to show this high degree of acetylation.

MeSH Terms
Acetylation Cell Line Cell Transformation, Neoplastic Histones/metabolism Mutation Polyomavirus/growth & development,metabolism Viral Proteins/metabolism
Chemicals
Histones Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schaffhausen B S
Benjamin T L
References (31)
31 references, click to expand
  1. Properties of the genome in normal and SV40 transformed WI38 human diploid fibroblasts. II. Metabolism and binding of histones.
    Exp Cell Res. 1975 Apr;92(1):175-90 PMID: 165950
  2. Analysis of host range of nontransforming polyoma virus mutants.
    Virology. 1975 Aug;66(2):372-84 PMID: 168683
  3. Fingerprints of polyoma virus proteins and mouse histones.
    Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:235-41 PMID: 169064
  4. Indirect complementation of a nontransforming mutant of polyoma virus.
    Cold Spring Harb Symp Quant Biol. 1975;39 Pt 1:41-4 PMID: 169086
  5. Studies on DNA from low-density particles of SV40. I. Heterogeneous defective virions produced by successive undiluted passages.
    Virology. 1968 Mar;34(3):391-401 PMID: 4297160
  6. Complementation and transformation by temperature-sensitive mutants of polyoma virus.
    Virology. 1969 May;38(1):120-5 PMID: 4306521
  7. Host range mutants of polyoma virus.
    Proc Natl Acad Sci U S A. 1970 Sep;67(1):394-9 PMID: 4318787
  8. Temperature-dependent properties of cells transformed by a thermosensitive mutant of polyoma virus.
    Proc Natl Acad Sci U S A. 1970 Dec;67(4):1775-81 PMID: 4321345
  9. Cyclic membrane changes in animal cells: transformed cells permanently display a surface architecture detected in normal cells only during mitosis.
    Proc Natl Acad Sci U S A. 1971 Jan;68(1):244-7 PMID: 4322263
  10. Quantitation of Simian virus 40 sequences in African green monkey, mouse and virus-transformed cell genomes.
    J Mol Biol. 1971 Apr 14;57(1):129-45 PMID: 4325134
  11. Properties and amino acid composition of polyoma virus purified by zonal ultracentrifugation.
    J Mol Biol. 1968 Aug 28;36(1):153-66 PMID: 4329658
  12. Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus.
    Proc Natl Acad Sci U S A. 1970 Oct;67(2):929-34 PMID: 4332911
  13. Polyoma virus basic proteins.
    J Gen Virol. 1972 Feb;14(2):141-55 PMID: 4334780
  14. Polyoma T antigen synthesis by temperature-sensitive mutants of polyoma virus.
    Virology. 1972 Sep;49(3):675-82 PMID: 4342080
  15. Polyoma gene function required for viral DNA synthesis.
    Virology. 1973 Sep;55(1):127-35 PMID: 4353950
  16. Complementation analysis of simian virus 40 mutants.
    J Virol. 1974 May;13(5):1101-9 PMID: 4363253
  17. Properties of the ts3 mutant of polyoma virus during lytic infection.
    Virology. 1974 Aug;60(2):359-69 PMID: 4367487
  18. Changes in histone acetyl content and in nuclear non-histone protein composition of avian erythroid cells at different stages of maturation.
    J Biol Chem. 1974 Nov 25;249(22):7358-68 PMID: 4436314
  19. Histone acetylation and hormone action. Early effects of oestradiol-17beta on histone acetylation in rat uterus.
    Biochem J. 1972 Dec;130(3):663-9 PMID: 4664926
  20. Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney.
    Biochem J. 1973 Aug;134(4):907-12 PMID: 4762763
  21. Separation and analysis of histone subfractions differing in their degree of acetylation: some correlations with genetic activity in development.
    Arch Biochem Biophys. 1972 May;150(1):44-56 PMID: 5028081
  22. Trout testis cells. 3. Acetylation of histones in different cell types from developing trout testis.
    J Biol Chem. 1972 Sep 10;247(17):5506-10 PMID: 5055780
  23. Histone phosphorylation in synchronized mammalian cell cultures.
    Arch Biochem Biophys. 1971 Jan;142(1):299-302 PMID: 5101855
  24. Histone acetylation in synchronized mammalian cell cultures.
    Biochim Biophys Acta. 1971 Jan 28;228(2):544-9 PMID: 5101931
  25. Methylation of lysine residues of histone fractions in synchronized mammalian cells.
    Arch Biochem Biophys. 1971 Mar;143(1):1-5 PMID: 5105464
  26. RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.
    Proc Natl Acad Sci U S A. 1966 Apr;55(4):805-12 PMID: 5219687
  27. Changing patterns of histone acetylation and RNA synthesis in regeneration of the liver.
    Proc Natl Acad Sci U S A. 1968 Apr;59(4):1337-44 PMID: 5240033
  28. Temperature-dependent surface changes in cells infected or transformed by a thermosensitive mutant of polyoma virus.
    Proc Natl Acad Sci U S A. 1971 Feb;68(2):283-6 PMID: 5277070
  29. Transient stimulation of deoxyribonucleic acid-dependent ribonucleic acid polymerase and histone acetylation in human embryonic kidney cultures infected with adenovirus 2 or 12: apparent induction of host ribonucleic acid synthesis.
    J Virol. 1970 Jul;6(1):58-68 PMID: 5471477
  30. High resolution acrylamide gel electrophoresis of histones.
    Arch Biochem Biophys. 1969 Mar;130(1):337-46 PMID: 5778650
  31. ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.
    Proc Natl Acad Sci U S A. 1964 May;51:786-94 PMID: 14172992
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.4.1092
Published
1976-04-00
Pages
1092-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430206
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.4.1092 PMC Full Text View journal details
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