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PMID: 17707914 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes.

Progress in lipid research ·Vol. 46 ·No. 6 ·2007-11-00 ·Pages 315-27

Kutateladze TG

Abstract

Phosphatidylinositol 3-phosphate [PtdIns(3)P], a phospholipid produced by PI 3-kinases in early endosomes and multivesicular bodies, often serves as a marker of endosomal membranes. PtdIns(3)P recruits and activates effector proteins containing the FYVE or PX domain and therefore regulates a variety of biological processes including endo- and exocytosis, membrane trafficking, protein sorting, signal transduction and cytoskeletal rearrangement. Structures and PtdIns(3)P binding modes of several FYVE and PX domains have recently been characterized, unveiling the molecular basis underlying multiple cellular functions of these proteins. Here, structural and functional aspects and current mechanisms of the multivalent membrane anchoring by the FYVE and PX domains are reviewed and compared.

MeSH Terms
Cell Membrane/metabolism Histidine/metabolism Humans Hydrophobic and Hydrophilic Interactions Membrane Proteins/metabolism Molecular Structure Phosphatidylinositol 3-Kinases/metabolism Phosphatidylinositol Phosphates/metabolism Protein Binding/physiology Static Electricity
Chemicals
Membrane Proteins Phosphatidylinositol Phosphates phosphatidylinositol 3-phosphate Histidine Phosphatidylinositol 3-Kinases PIKFYVE protein, human
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kutateladze Tatiana G
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. Tatiana.Kutateladze@UCHSC.edu
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Article Info
Journal
Progress in lipid research
Abbr.
Prog Lipid Res
ISSN
0163-7827
DOI
10.1016/j.plipres.2007.06.001
Email
tatiana.kutateladze@uchsc.edu
Published
2007-11-00
Epub
2007-00-13
Pages
315-27
Language
English
Region
England
NLM ID
7900832
PMCID
PMC2211451
Subset
IM
Grants
NIGMS NIH HHS · R01 GM071424 · United States
NCI NIH HHS · R01 CA113472 · United States
NIGMS NIH HHS · GM 071424 · United States
NIGMS NIH HHS · R01 GM071424-02 · United States
NCI NIH HHS · CA 113472 · United States
NCI NIH HHS · R01 CA113472-02 · United States
External Links
PubMed source DOI: 10.1016/j.plipres.2007.06.001 PMC Full Text View journal details
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