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PMID: 17673165 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors.

Biochimica et biophysica acta ·Vol. 1778 ·No. 9 ·2008-09-00 ·Pages 1930-45

Brooks BE, Buchanan SK

Abstract

A variety of mechanisms are used to signal extracytoplasmic conditions to the cytoplasm. These mechanisms activate extracytoplasmic function (ECF) sigma factors which recruit RNA-polymerase to specific genes in order to express appropriate proteins in response to the changing environment. The two best understood ECF signaling pathways regulate sigma(E)-mediated expression of periplasmic stress response genes in Escherichia coli and FecI-mediated expression of iron-citrate transport genes in E. coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria.

MeSH Terms
Biological Transport/physiology Citric Acid/metabolism Cytoplasm/metabolism,physiology Escherichia coli/genetics Escherichia coli Proteins/chemistry,metabolism Iron/metabolism Membrane Proteins/chemistry,metabolism Models, Biological Models, Molecular Sigma Factor/metabolism,physiology Signal Transduction/physiology Stress, Physiological/genetics,metabolism Transcription Factors/chemistry,metabolism
Chemicals
Escherichia coli Proteins FecI protein, E coli Membrane Proteins RseA protein, E coli Sigma Factor Transcription Factors Citric Acid Iron
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brooks Benjamin E
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Buchanan Susan K
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamem.2007.06.005
Published
2008-09-00
Epub
2007-00-15
Pages
1930-45
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2562455
Subset
IM
Grants
Intramural NIH HHS · Z01 DK036142-01 · United States
External Links
PubMed source DOI: 10.1016/j.bbamem.2007.06.005 PMC Full Text
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