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PMID: 17664434 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

New directions in single-molecule imaging and analysis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 104 ·No. 31 ·2007-07-31 ·Pages 12596-602

Moerner WE

Abstract

Optical imaging and analysis of single molecules continue to unfold as powerful ways to study the individual behavior of biological systems, unobscured by ensemble averaging. Current expansion of interest in this field is great, as evidenced by new meetings, journal special issues, and the large number of new investigators. Selected recent advances in biomolecular analysis are described, and two new research directions are summarized: superresolution imaging using single-molecule fluorescence and trapping of single molecules in solution by direct suppression of Brownian motion.

MeSH Terms
Biomedical Technology/instrumentation,methods DNA/analysis PubMed Solutions Time Factors
Chemicals
Solutions DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Moerner W E
Department of Chemistry, Stanford University, Stanford, CA 94305, USA. wmoerner@stanford.edu
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0610081104
Email
wmoerner@stanford.edu
Published
2007-07-31
Epub
2007-00-30
Pages
12596-602
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1937512
Subset
IM
Grants
NCRR NIH HHS · R21 RR023149-02 · United States
NIGMS NIH HHS · R21 GM075166-02 · United States
NIGMS NIH HHS · R21 GM075166 · United States
NHGRI NIH HHS · P20 HG003638 · United States
NHGRI NIH HHS · P20 HG003638-04 · United States
NCRR NIH HHS · 1R21 RR 023149 · United States
NHGRI NIH HHS · 1P20 HG 003638 · United States
NIGMS NIH HHS · 1R21 GM 075166 · United States
NCRR NIH HHS · R21 RR023149-01 · United States
NCRR NIH HHS · R21 RR023149 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1073/pnas.0610081104 PMC Full Text View journal details
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