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PMID: 17652583 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 27 ·No. 30 ·2007-07-25 ·Pages 7921-8

Kourrich S, Rothwell PE, Klug JR, Thomas MJ

Abstract

Plasticity of glutamatergic synapses is a fundamental mechanism through which experience changes neural function to impact future behavior. In animal models of addiction, glutamatergic signaling in the nucleus accumbens (NAc) exerts powerful control over drug-seeking behavior. However, little is known about whether, how or when experience with drugs may trigger synaptic plasticity in this key nucleus. Using whole-cell synaptic physiology in NAc brain slices, we demonstrate that a progression of bidirectional changes in glutamatergic synaptic strength occurs after repeated in vivo exposure to cocaine. During a protracted drug-free period, NAc neurons from cocaine-experienced mice develop a robust potentiation of AMPAR-mediated synaptic transmission. However, a single re-exposure to cocaine during extended withdrawal becomes a potent stimulus for synaptic depression, abruptly reversing the initial potentiation. These enduring modifications in AMPAR-mediated responses and plasticity may provide a neural substrate for disrupted processing of drug-related stimuli in drug-experienced individuals.

MeSH Terms
Animals Cocaine/administration & dosage Cocaine-Related Disorders/physiopathology,psychology Excitatory Postsynaptic Potentials/drug effects,physiology Male Mice Mice, Inbred C57BL Motor Activity/drug effects,physiology Nerve Net/drug effects,physiology Neuronal Plasticity/drug effects,physiology Nucleus Accumbens/drug effects,physiology Synapses/drug effects,physiology
Chemicals
Cocaine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kourrich Saïd
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Rothwell Patrick E
Klug Jason R
Thomas Mark J
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.1859-07.2007
Published
2007-07-25
Pages
7921-8
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6672735
Subset
IM
Grants
NIDA NIH HHS · R01 DA019666 · United States
NIDA NIH HHS · T32 DA007234 · United States
NIDA NIH HHS · T32 DA07234 · United States
Corrections
CommentIn
PMID: 18354000
External Links
PubMed source DOI: 10.1523/JNEUROSCI.1859-07.2007 PMC Full Text View journal details
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