Abstract
In the visual cortex, as elsewhere, N-methyl-D-aspartate receptors (NMDARs) play a critical role in triggering long-term, experience-dependent synaptic plasticity. Modifications of NMDAR subunit composition alter receptor function, and could have a large impact on the properties of synaptic plasticity. We have used immunoblot analysis to investigate the effects of age and visual experience on the expression of different NMDAR subunits in synaptoneurosomes prepared from rat visual cortices. NMDARs at birth are comprised of NR2B and NR1 subunits, and, over the first 5 postnatal weeks, there is a progressive inclusion of the NR2A subunit. Dark rearing from birth attenuates the developmental increase in NR2A. Levels of NR2A increase rapidly (in <2 hr) when dark-reared animals are exposed to light, and decrease gradually over the course of 3 to 4 days when animals are deprived of light. These data reveal that NMDAR subunit composition in the visual cortex is remarkably dynamic and bidirectionally regulated by sensory experience. We propose that NMDAR subunit regulation is a mechanism for experience-dependent modulation of synaptic plasticity in the visual cortex, and serves to maintain synaptic strength within an optimal dynamic range.
MeSH Terms
Animals
Female
Kinetics
Male
Microscopy, Electron
Nerve Tissue Proteins/metabolism
Rats
Rats, Long-Evans
Receptors, N-Methyl-D-Aspartate/chemistry,metabolism,physiology
Synapses/metabolism,ultrastructure
Visual Cortex/growth & development,metabolism
Chemicals
Nerve Tissue Proteins
Receptors, N-Methyl-D-Aspartate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Quinlan E M
Howard Hughes Medical Institute, Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Olstein D H
Bear M F
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