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PMID: 176428 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Persistent reovirus infection of CHO cells resulting in virus resistance.

Journal of virology ·Vol. 17 ·No. 2 ·1976-02-00 ·Pages 513-24

Taber R, Alexander V, Whitford W

Abstract

We obtained a persistently infected line of Chinese hamster ovary cells by selection for resistance to reovirus infection. The cells were persistently infected by a population of viruses that were (i) cytopathic for parental chinese hamster ovary cells and (ii) similar to wild-type reovirus in molecular characteristics. The growth rate, plating efficiency, and morphology of the cells were altered. A large majority of the cells in the population were infected. There was no detectable interferon present in the medium. The cells were relatively resistant to a wide range of viruses.

MeSH Terms
Animals Cricetinae Cytopathogenic Effect, Viral Encephalomyocarditis virus/growth & development Female Microscopy, Electron Microscopy, Electron, Scanning Newcastle disease virus/growth & development Reoviridae/growth & development,ultrastructure Vesicular stomatitis Indiana virus/growth & development Viral Interference
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taber R
Alexander V
Whitford W
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24 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.17.2.513-524.1976
Published
1976-02-00
Pages
513-24
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC515443
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.17.2.513-524.1976 PMC Full Text View journal details
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