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PMID: 17629396 Published · ppublish English Journal Article Review

Role of chemokines in tumor growth.

Cancer letters ·Vol. 256 ·No. 2 ·2007-10-28 ·Pages 137-65

Raman D, Baugher PJ, Thu YM, Richmond A

Abstract

Chemokines play a paramount role in the tumor progression. Chronic inflammation promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and cytokines. These act either by autocrine or paracrine mechanisms to sustain tumor cell growth, induce angiogenesis and facilitate evasion of immune surveillance through immunoediting. The chemokine receptor CXCR2 and its ligands promote tumor angiogenesis and leukocyte infiltration into the tumor microenvironment. In harsh acidic and hypoxic microenvironmental conditions tumor cells up-regulate their expression of CXCR4, which equips them to migrate up a gradient of CXCL12 elaborated by carcinoma-associated fibroblasts (CAFs) to a normoxic microenvironment. The CXCL12-CXCR4 axis facilitates metastasis to distant organs and the CCL21-CCR7 chemokine ligand-receptor pair favors metastasis to lymph nodes. These two chemokine ligand-receptor systems are common key mediators of tumor cell metastasis for several malignancies and as such provide key targets for chemotherapy. In this paper, the role of specific chemokines/chemokine receptor interactions in tumor progression, growth and metastasis and the role of chemokine/chemokine receptor interactions in the stromal compartment as related to angiogenesis, metastasis, and immune response to the tumor are reviewed.

MeSH Terms
Animals Antineoplastic Agents/pharmacology,therapeutic use Chemokines/metabolism Endothelial Cells/metabolism,pathology Humans Inflammation/immunology,metabolism,pathology Leukocytes/metabolism,pathology Neoplasm Metastasis Neoplasms/blood supply,drug therapy,immunology,metabolism,pathology Neovascularization, Pathologic/metabolism Receptors, Chemokine/drug effects,metabolism Signal Transduction/drug effects Stromal Cells/metabolism,pathology
Chemicals
Antineoplastic Agents Chemokines Receptors, Chemokine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Raman Dayanidhi
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Baugher Paige J
Thu Yee Mon
Richmond Ann
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Article Info
Journal
Cancer letters
Abbr.
Cancer Lett
ISSN
0304-3835
DOI
10.1016/j.canlet.2007.05.013
Published
2007-10-28
Epub
2007-00-12
Pages
137-65
Language
English
Region
Ireland
NLM ID
7600053
PMCID
PMC2065851
Subset
IM
Grants
NCI NIH HHS · R01 CA116021-03 · United States
NCI NIH HHS · R01 CA034590 · United States
NCI NIH HHS · T32 CA009592 · United States
NCI NIH HHS · R01 CA116021 · United States
BLRD VA · IK6 BX005225 · United States
NCI NIH HHS · R01 CA034590-24 · United States
External Links
PubMed source DOI: 10.1016/j.canlet.2007.05.013 PMC Full Text View journal details
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