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PMID: 17569640 Published · ppublish English Journal Article Review

Valvulogenesis: the moving target.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 362 ·No. 1484 ·2007-08-29 ·Pages 1489-503

Butcher JT, Markwald RR

Abstract

Valvulogenesis is an extremely complex process by which a fragile gelatinous matrix is populated and remodelled during embryonic development into thin fibrous leaflets capable of maintaining unidirectional flow over a lifetime. This process occurs during exposure to constantly changing haemodynamic forces, with a success rate of approximately 99%. Defective valvulogenesis results in impaired cardiac function and lifelong complications. This review integrates what is known about the roles of genetics and mechanics in the development of valves and how changes in either result in impaired morphogenesis. It is hoped that appropriate developmental cues and phenotypic endpoints could help engineers and clinicians in their efforts to regenerate living valve alternatives.

MeSH Terms
Animals Heart Valves/embryology Humans Organogenesis Signal Transduction/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Butcher Jonathan T
Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14853, USA. jtb47@cornell.edu
Markwald Roger R
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.2007.2130
Email
jtb47@cornell.edu
Published
2007-08-29
Pages
1489-503
Language
English
Region
England
NLM ID
7503623
PMCID
PMC2440410
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.2007.2130 PMC Full Text View journal details
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