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PMID: 17566854 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Organotropism of breast cancer metastasis.

Journal of mammary gland biology and neoplasia ·Vol. 12 ·No. 2-3 ·2007-09-00 ·Pages 153-62

Lu X, Kang Y

Abstract

Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.

MeSH Terms
Animals Bone Neoplasms/metabolism,pathology,secondary Breast Neoplasms/metabolism,pathology Humans Lung Neoplasms/genetics,metabolism,pathology,secondary Neoplasm Metastasis/pathology Neoplastic Stem Cells/metabolism,pathology RANK Ligand/metabolism
Chemicals
RANK Ligand
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lu Xin
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA.
Kang Yibin
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1007/s10911-007-9047-3
Published
2007-09-00
Pages
153-62
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1007/s10911-007-9047-3 View journal details
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