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PMID: 17145848 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Preparing the "soil": the premetastatic niche.

Cancer research ·Vol. 66 ·No. 23 ·2006-12-01 ·Pages 11089-93

Kaplan RN, Rafii S, Lyden D

Abstract

Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of fibronectin and clustering of bone marrow-derived cellular infiltrates coexpressing matrix metalloproteinases in distant tissue sites before tumor cell arrival are proving to be indispensable for the initial stages of metastasis. These bone marrow-derived hematopoietic progenitors that express vascular endothelial growth factor receptor 1 mobilize in response to the unique array of growth factors produced by the primary tumor. Their arrival in distant sites represents early changes in the local microenvironment, termed the "premetastatic niche," which dictate the pattern of metastatic spread. Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception.

MeSH Terms
Bone Marrow Cells/metabolism,pathology Cell Adhesion/physiology Chemokines/metabolism Fibronectins/metabolism Humans Matrix Metalloproteinases/metabolism Models, Biological Neoplasm Metastasis/pathology,physiopathology Neoplasms/metabolism,pathology,physiopathology Vascular Endothelial Growth Factor Receptor-1/metabolism
Chemicals
Chemokines Fibronectins Vascular Endothelial Growth Factor Receptor-1 Matrix Metalloproteinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kaplan Rosandra N
Department of Pediatrics, Weill College of Medicine at Cornell University, New York, NY 10021, USA.
Rafii Shahin
Lyden David
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Article Info
Journal
Cancer research
Abbr.
Cancer Res
ISSN
0008-5472
DOI
10.1158/0008-5472.CAN-06-2407
Published
2006-12-01
Pages
11089-93
Language
English
Region
United States
NLM ID
2984705R
PMCID
PMC2952469
Subset
IM
Grants
NHLBI NIH HHS · P01 HL067839-020004 · United States
NHLBI NIH HHS · R01 HL061849-04 · United States
NCI NIH HHS · R01CA098234 · United States
NHLBI NIH HHS · R01 HL058707-04 · United States
NHLBI NIH HHS · P01 HL067839 · United States
NCI NIH HHS · R01 CA098234 · United States
NHLBI NIH HHS · R01 HL058707-03 · United States
NHLBI NIH HHS · R01 HL061849-03S1 · United States
Howard Hughes Medical Institute · United States
NHLBI NIH HHS · R01 HL061849-03 · United States
NHLBI NIH HHS · R01 HL061849 · United States
NHLBI NIH HHS · R01 HL061849-05 · United States
NHLBI NIH HHS · P01 HL067839-050004 · United States
NHLBI NIH HHS · P01 HL067839-030004 · United States
NHLBI NIH HHS · P01 HL067839-010004 · United States
NHLBI NIH HHS · R01 HL061849-02 · United States
NHLBI NIH HHS · P01 HL067839-040004 · United States
External Links
PubMed source DOI: 10.1158/0008-5472.CAN-06-2407 PMC Full Text View journal details
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