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PMID: 17517435 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The long and arduous road to CRAC.

Cell calcium ·Vol. 42 ·No. 2 ·2007-08-00 ·Pages 157-62

Vig M, Kinet JP

Abstract

Store-operated calcium (SOC) entry is the major route of calcium influx in non-excitable cells, especially immune cells. The best characterized store-operated current, I(CRAC), is carried by calcium release activated calcium (CRAC) channels. The existence of the phenomenon of store-operated calcium influx was proposed almost two decades ago. However, in spite of rigorous research by many laboratories, the identity of the key molecules participating in the process has remained a mystery. In all these years, multiple different approaches have been adopted by countless researchers to identify the molecular players in this fundamental process. Along the way, many crucial discoveries have been made, some of which have been summarized here. The last couple of years have seen significant breakthroughs in the field-identification of STIM1 as the store Ca(2+) sensor and CRACM1 (Orai1) as the pore-forming subunit of the CRAC channel. The field is now actively engaged in deciphering the gating mechanism of CRAC channels. We summarize here the latest progress in this direction.

MeSH Terms
Animals Caenorhabditis elegans Proteins/genetics,physiology Calcium Channels/metabolism Drosophila Proteins/genetics,physiology Mast Cells/immunology Membrane Proteins/genetics,physiology ORAI1 Protein TRPC Cation Channels/genetics,physiology
Chemicals
Caenorhabditis elegans Proteins Calcium Channels Drosophila Proteins Membrane Proteins ORAI1 Protein TRPC Cation Channels olf186-F protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vig Monika
Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Kinet Jean-Pierre
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Article Info
Journal
Cell calcium
Abbr.
Cell Calcium
ISSN
0143-4160
DOI
10.1016/j.ceca.2007.03.008
Published
2007-08-00
Epub
2007-00-22
Pages
157-62
Language
English
Region
Netherlands
NLM ID
8006226
PMCID
PMC2001162
Subset
IM
Grants
NIGMS NIH HHS · R37 GM053950 · United States
NIGMS NIH HHS · R37 GM053950-12 · United States
NIGMS NIH HHS · 5-R37-GM053950 · United States
External Links
PubMed source DOI: 10.1016/j.ceca.2007.03.008 PMC Full Text View journal details
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