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PMID: 17496832 Published · ppublish English Congress Research Support, Non-U.S. Gov't

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis.

EMBO reports ·Vol. 8 ·No. 6 ·2007-06-00 ·Pages 537-41

Lichtenthaler SF, Steiner H

Abstract

暂无摘要

MeSH Terms
Animals Catalysis Cell Membrane/enzymology Humans Mice Peptide Hydrolases/chemistry,metabolism Protein Processing, Post-Translational Substrate Specificity
Chemicals
Peptide Hydrolases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lichtenthaler Stefan F
Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory of Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany. stefan.lichtenthaler@med.uni-muenchen.de
Steiner Harald
References (18)
18 references, click to expand
  1. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.
    Cell. 2000 Feb 18;100(4):391-8 PMID: 10693756
  2. Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate.
    Proc Natl Acad Sci U S A. 2007 May 15;104(20):8257-62 PMID: 17463085
  3. Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
    EMBO J. 2005 Feb 9;24(3):464-72 PMID: 15616571
  4. Serine proteases from two cell types target different components of a complex that governs regulated intramembrane proteolysis of pro-sigmaK during Bacillus subtilis development.
    Mol Microbiol. 2005 Nov;58(3):835-46 PMID: 16238631
  5. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
    J Neurosci. 2006 Apr 5;26(14):3821-8 PMID: 16597736
  6. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.
    Proc Natl Acad Sci U S A. 2006 May 2;103(18):6889-94 PMID: 16636269
  7. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.
    Nat Cell Biol. 2006 Aug;8(8):894-6 PMID: 16829951
  8. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.
    Nat Cell Biol. 2006 Aug;8(8):843-8 PMID: 16829952
  9. Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
    J Biol Chem. 2006 Sep 15;281(37):27633-42 PMID: 16844686
  10. Control of peripheral nerve myelination by the beta-secretase BACE1.
    Science. 2006 Oct 27;314(5799):664-6 PMID: 16990514
  11. Crystal structure of a rhomboid family intramembrane protease.
    Nature. 2006 Nov 9;444(7116):179-80 PMID: 17051161
  12. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
    J Neurosci. 2006 Nov 15;26(46):12081-8 PMID: 17108181
  13. ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
    Nat Immunol. 2006 Dec;7(12):1293-8 PMID: 17072319
  14. Bace1 modulates myelination in the central and peripheral nervous system.
    Nat Neurosci. 2006 Dec;9(12):1520-5 PMID: 17099708
  15. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.
    Nat Struct Mol Biol. 2006 Dec;13(12):1084-91 PMID: 17099694
  16. Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.
    Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):1003-8 PMID: 17215357
  17. Open-cap conformation of intramembrane protease GlpG.
    Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2098-102 PMID: 17277078
  18. Intramembrane proteolysis: theme and variations.
    Science. 2004 Aug 20;305(5687):1119-23 PMID: 15326347
Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
Published
2007-06-00
Epub
2007-00-11
Pages
537-41
Language
English
Region
England
NLM ID
100963049
PMCID
PMC2002526
Subset
IM
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