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PMID: 17415525 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells.

Journal of neuro-oncology ·Vol. 84 ·No. 1 ·2007-08-00 ·Pages 21-9

Ping YF, Yao XH, Chen JH, Liu H, Chen DL, Zhou XD, Wang JM, Bian XW

Abstract

The chemokine receptor CXCR4 plays an important role in tumor growth, angiogenesis and metastasis. Our previous studies showed that Nordy, a synthetic chiral compound of nordihydroguaiaretic acid, inhibited the growth and angiogenesis of various malignant tumors. In this study we examined the capacity of Nordy to regulate CXCR4-mediated production of angiogenic factors by human glioblastoma cells. We found that Nordy potently inhibited CXCR4 ligand SDF-1-induced production of IL-8 and vascular endothelial cell growth factor, two important angiogenic factors implicated in the progression of malignant tumors. Further study revealed that the effect of Nordy was attributable to its down-regulation of the expression of functional CXCR4 in glioblastoma cells. These results suggest that the anti-cancer activity of Nordy is due, at least in part, to its suppression of the chemokine receptor CXCR4 thus reducing the production of angiogenic factors by tumor cells.

MeSH Terms
Analysis of Variance Angiogenic Proteins/metabolism Animals Antineoplastic Agents/pharmacology Brain Neoplasms/drug therapy,metabolism Cell Line, Tumor Down-Regulation Gene Expression Regulation, Neoplastic/drug effects Glioma/drug therapy,metabolism Humans Interleukin-8/genetics,metabolism Lignans/pharmacology Lipoxygenase Inhibitors/pharmacology Masoprocol/chemistry,pharmacology Mice Mice, Inbred BALB C Mice, Nude RNA, Messenger/analysis Receptors, CXCR4/drug effects,metabolism Vascular Endothelial Growth Factor A/drug effects,genetics,metabolism
Chemicals
Angiogenic Proteins Antineoplastic Agents Interleukin-8 Lignans Lipoxygenase Inhibitors RNA, Messenger Receptors, CXCR4 Vascular Endothelial Growth Factor A nordy Masoprocol
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ping Yi-fang
Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Yao Xiao-hong
Chen Jian-hong
Liu Hong
Chen Dai-lun
Zhou Xiang-dong
Wang Ji Ming
Bian Xiu-wu
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Article Info
Journal
Journal of neuro-oncology
Abbr.
J Neurooncol
ISSN
0167-594X
DOI
10.1007/s11060-007-9349-8
Published
2007-08-00
Epub
2007-00-06
Pages
21-9
Language
English
Region
United States
NLM ID
8309335
Subset
IM
External Links
PubMed source DOI: 10.1007/s11060-007-9349-8 View journal details
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