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PMID: 17399958 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

TRP channels in hypertension.

Biochimica et biophysica acta ·Vol. 1772 ·No. 8 ·2007-08-00 ·Pages 895-906

Firth AL, Remillard CV, Yuan JX

Abstract

Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca(2+) homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged at the forefront of research into hypertensive disease states. TRP channels are identified as molecular correlates for receptor-operated and store-operated cation channels in the vasculature. Over 10 TRP isoforms are identified at the mRNA and protein expression levels in the vasculature. Current research implicates upregulation of specific TRP isoforms to be associated with increased Ca(2+) influx, characteristic of vasoconstriction and vascular smooth muscle cell proliferation. TRP channels are implicated as Ca(2+) entry pathways in pulmonary hypertension and essential hypertension. Caveolae have recently emerged as membrane microdomains in which TRP channels may be co-localized with the endoplasmic reticulum in both smooth muscle and endothelial cells. Such enhanced expression and function of TRP channels and their localization in caveolae in pathophysiological hypertensive disease states highlights their importance as potential targets for pharmacological intervention.

MeSH Terms
Animals Caveolae/metabolism Cell Proliferation/drug effects Cytoskeleton/metabolism Endothelium, Vascular/drug effects,metabolism Gene Expression Regulation Humans Hypertension/etiology,genetics,physiopathology,therapy Hypertension, Pulmonary/etiology,genetics,therapy Models, Biological Muscle Contraction/drug effects Muscle, Smooth, Vascular/drug effects,metabolism,physiology Pulmonary Artery/physiology Transient Receptor Potential Channels/agonists,genetics,metabolism,physiology
Chemicals
Transient Receptor Potential Channels
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Firth Amy L
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0725, La Jolla, CA 92093-0725, USA.
Remillard Carmelle V
Yuan Jason X-J
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbadis.2007.02.009
Published
2007-08-00
Epub
2007-00-01
Pages
895-906
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2025589
Subset
IM
Grants
NHLBI NIH HHS · R29 HL054043 · United States
NHLBI NIH HHS · HL 064945 · United States
NHLBI NIH HHS · R01 HL064945-08 · United States
NHLBI NIH HHS · R01 HL054043-12 · United States
NHLBI NIH HHS · HL 054043 · United States
NHLBI NIH HHS · R01 HL054043 · United States
NHLBI NIH HHS · HL 066012 · United States
NHLBI NIH HHS · R01 HL066012-06 · United States
NHLBI NIH HHS · R01 HL064945 · United States
NHLBI NIH HHS · R01 HL066012 · United States
External Links
PubMed source DOI: 10.1016/j.bbadis.2007.02.009 PMC Full Text
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