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PMID: 17395433 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?

Biochimica et biophysica acta ·Vol. 1772 ·No. 8 ·2007-08-00 ·Pages 822-35

Hermosura MC, Garruto RM

Abstract

Recent findings implicating TRPM7 and TRPM2 in oxidative stress-induced neuronal death thrust these channels into the spotlight as possible therapeutic targets for neurodegenerative diseases. In this review, we describe how the functional properties of TRPM7 and TRPM2 are interconnected with calcium (Ca(2+)) and magnesium (Mg(2+)) homeostasis, oxidative stress, mitochondrial dysfunction, and immune mechanisms, all principal suspects in neurodegeneration. We focus our discussion on Western Pacific Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism Dementia (PD) because extensive studies conducted over the years strongly suggest that these diseases are ideal candidates for a gene-environment model of etiology. The unique mineral environment identified in connection with Western Pacific ALS and PD, low Mg(2+) and Ca(2+), yet high in transition metals, creates a condition that could affect the proper function of these two channels.

MeSH Terms
Amyotrophic Lateral Sclerosis/genetics,pathology Cell Death Dementia/genetics Environment Genetic Predisposition to Disease Humans Microglia/metabolism Mitochondria/pathology Neurons/physiology Oxidative Stress/physiology Parkinsonian Disorders/genetics Protein Serine-Threonine Kinases Reactive Nitrogen Species/pharmacology TRPM Cation Channels/genetics,metabolism,physiology
Chemicals
Reactive Nitrogen Species TRPM Cation Channels TRPM2 protein, human Protein Serine-Threonine Kinases TRPM7 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hermosura Meredith C
Bekesy Laboratory of Neurobiology, Pacific Biosciences Research Center, University of Hawaii at Manoa, 1993 East-West Road, Honolulu, HI 96822, USA. meredith@pbrc.hawaii.edu
Garruto Ralph M
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbadis.2007.02.008
Email
meredith@pbrc.hawaii.edu
Published
2007-08-00
Epub
2007-00-24
Pages
822-35
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC1994999
Subset
IM
Grants
NINDS NIH HHS · S11 NS043462 · United States
NINDS NIH HHS · S11 NS043462-05 · United States
External Links
PubMed source DOI: 10.1016/j.bbadis.2007.02.008 PMC Full Text
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