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PMID: 17318269 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Microenvironment of the involuting mammary gland mediates mammary cancer progression.

Journal of mammary gland biology and neoplasia ·Vol. 12 ·No. 1 ·2007-03-00 ·Pages 71-82

Schedin P, O'Brien J, Rudolph M, Stein T, Borges V

Abstract

Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.

MeSH Terms
Breast Neoplasms/pathology Female Humans Lactation Mammary Glands, Human/pathology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schedin Pepper
AMC Cancer Research Center, University of Colorado Health Science Center, Aurora, CO, USA. Pepper.schedin@uchsc.edu
O'Brien Jenean
Rudolph Michael
Stein Torsten
Borges Virginia
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1007/s10911-007-9039-3
Email
pepper.schedin@uchsc.edu
Published
2007-03-00
Pages
71-82
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · R01 CA85944 · United States
External Links
PubMed source DOI: 10.1007/s10911-007-9039-3 View journal details
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