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PMID: 10426397 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Adhesion-mediated signaling in the regulation of mammary epithelial cell survival.

Journal of mammary gland biology and neoplasia ·Vol. 4 ·No. 2 ·1999-04-00 ·Pages 183-91

Streuli CH, Gilmore AP

Abstract

Tissue architecture in multicellular organisms is maintained through adhesive interactions between cells and their neighbors, and between cells and the underlying extracellular matrix. These interactions are important in the dynamic regulation of tissue organization as well as the control of cell proliferation, differentiation and apoptosis. The ultimate goal of this regulation is to promote cell growth and differentiation only when the cell is in the correct location, and to delete cells that have become displaced from their proper environment. It therefore plays an important role in development and tissue remodeling. In this review we consider the molecular mechanisms by which cell-matrix interactions contribute to cell survival, and discuss their role in mammary gland development and function.

MeSH Terms
Animals Apoptosis Basement Membrane/physiology Breast/cytology,physiology Cell Adhesion/physiology Cell Survival Epithelial Cells/cytology,physiology Extracellular Matrix/physiology Female Humans Mammary Glands, Animal/cytology,physiology Models, Biological Signal Transduction/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Streuli C H
School of Biological Sciences, University of Manchester, United Kingdom. charles.streuli@man.ac.uk
Gilmore A P
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1018729308878
Email
charles.streuli@man.ac.uk
Published
1999-04-00
Pages
183-91
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1018729308878 View journal details
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