Integrins: emerging paradigms of signal transduction.

Annual review of cell and developmental biology ·Vol. 11 ·1995-00-00 ·Pages 549-99

Schwartz MA, Schaller MD, Ginsberg MH

Abstract

Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular signaling pathways. These signals converse with pathways that are initiated by soluble ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events to orchestrate complex cellular behavior.

MeSH Terms

Animals Cell Adhesion Cell Membrane/physiology,ultrastructure Extracellular Matrix/physiology Extracellular Matrix Proteins/metabolism Fibronectins/biosynthesis,metabolism GTP-Binding Proteins/metabolism Gene Expression Humans Integrins/physiology Ligands Lipid Metabolism Models, Biological Protein-Tyrosine Kinases/metabolism Signal Transduction

Chemicals

Extracellular Matrix Proteins Fibronectins Integrins Ligands Protein-Tyrosine Kinases GTP-Binding Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Schwartz M A

Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA.

Schaller M D

Ginsberg M H

Article Info

Journal

Annual review of cell and developmental biology

Abbr.

Annu Rev Cell Dev Biol

ISSN

1081-0706

DOI

10.1146/annurev.cb.11.110195.003001

Published

1995-00-00

Pages

549-99

Language

English

Region

United States

NLM ID

9600627

Subset

External Links

PubMed source DOI: 10.1146/annurev.cb.11.110195.003001 View journal details

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