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PMID: 17314969 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Scratching the surface of skin development.

Nature ·Vol. 445 ·No. 7130 ·2007-02-22 ·Pages 834-42

Fuchs E

Abstract

The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.

MeSH Terms
Animals Hair/cytology,growth & development Hair Follicle/cytology Humans Regenerative Medicine Sebaceous Glands/cytology,growth & development Skin/cytology,embryology,growth & development Stem Cells/cytology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Fuchs Elaine
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA. fuchslb@rockefeller.edu
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature05659
Email
fuchslb@rockefeller.edu
Published
2007-02-22
Pages
834-42
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2405926
Subset
IM
Grants
NIAMS NIH HHS · R01 AR027883-28 · United States
External Links
PubMed source DOI: 10.1038/nature05659 PMC Full Text View journal details
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