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PMID: 172895 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evolution of type C viral genes: preservation of ancestral murine type C viral sequences in pig cellular DNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 10 ·1975-10-00 ·Pages 4090-4

Benveniste RE, Todaro GJ

Abstract

Domestic pigs (Sus scrofa) and other members of the family Suidae have multiple copies of type C viral gene sequences in the cellular DNA of all their tissues. Partially homologous viral gene sequences are also found in cellular DNA of rodents, particularly Muridae. The results lead to the conclusion that type C viral genes were introduced into the Suidae lineage as a result of trans-species infection by an ancestral xenotropic murine virus. The rate of evolution of the virogene sequences in the pig appears to be much slower than that of genes that have remained in the rodent lineage; this may be a consequence of transfer from a shorter-lived animal (the rodent) to a longer-lived one (the pig). We estimate the time of gene transmission as 5-10 million years ago and conclude that the present-day porcine type C virogenes most closely approximate the viral genes as they were several million years ago in the rodent lineage.

MeSH Terms
Animals Biological Evolution DNA/analysis Genes Mice Nucleic Acid Hybridization Retroviridae Species Specificity Swine
Chemicals
DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benveniste R E
Todaro G J
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20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.10.4090
Published
1975-10-00
Pages
4090-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433144
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.10.4090 PMC Full Text View journal details
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