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PMID: 17282993 Published · ppublish English Journal Article Review

Evaluation of neural plasticity in adult stem cells.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 363 ·No. 1489 ·2008-01-12 ·Pages 199-205

Ross JJ, Verfaillie CM

Abstract

The role of stem cells has long been known in reproductive organs and various tissues including the haematopoietic system and skin. During the last decade, stem cells have also been identified in other organs, including the nervous system, both during development and in post-natal life. More recently, evidence has been presented that stem cells thought to be responsible for the generation of mature differentiated cells of one organ, such as haematopoietic stem cells, may have the ability to also differentiate across lineages and contribute to tissues other than haematopoietic cells, including neuronal tissue, suggesting that easily accessible stem cells sources may one day be useful in the therapy of ischaemic (stroke) and also degenerative diseases of the nervous system. Here, we will evaluate the validity of such claims based on a number of criteria we believe need to be fulfilled to definitively conclude that certain stem cells can give rise to functional neural cells that might be suitable for therapy of neural disorders.

MeSH Terms
Adult Stem Cells/physiology Animals Cell Differentiation/physiology Neuronal Plasticity/physiology Neurons/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ross Jeffrey J
Stem Cell Institute, Cell Biology and Development, University of Minnesota Medical School, MN 55455, USA.
Verfaillie Catherine M
References (82)
82 references, click to expand
  1. Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury.
    J Neurotrauma. 2001 Aug;18(8):813-9 PMID: 11526987
  2. Mesenchymal stem cells.
    J Orthop Res. 1991 Sep;9(5):641-50 PMID: 1870029
  3. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.
    Nature. 2003 Oct 30;425(6961):968-73 PMID: 14555960
  4. Mesenchymal stem cells: clinical applications and biological characterization.
    Int J Biochem Cell Biol. 2004 Apr;36(4):568-84 PMID: 15010324
  5. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells.
    Circulation. 2004 Sep 28;110(13):1847-54 PMID: 15381647
  6. Mouse neural progenitor cells differentiate into oligodendrocytes in the brain of a knockout mouse model of Canavan disease.
    Brain Res Dev Brain Res. 2004 Oct 15;153(1):19-27 PMID: 15464214
  7. Lack of a fusion requirement for development of bone marrow-derived epithelia.
    Science. 2004 Jul 2;305(5680):90-3 PMID: 15232107
  8. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery.
    Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2199-204 PMID: 11854516
  9. The adult rat hippocampus contains primordial neural stem cells.
    Mol Cell Neurosci. 1997;8(6):389-404 PMID: 9143557
  10. Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution.
    Stem Cells. 2006 Apr;24(4):1121-7 PMID: 16373692
  11. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.
    J Clin Invest. 2005 Feb;115(2):326-38 PMID: 15690083
  12. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.
    Radiat Res. 1961 Feb;14:213-22 PMID: 13776896
  13. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.
    Cell Transplant. 2003;12(3):201-13 PMID: 12797375
  14. Neural progenitors from human embryonic stem cells.
    Nat Biotechnol. 2001 Dec;19(12):1134-40 PMID: 11731782
  15. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.
    Nat Med. 2005 Apr;11(4):367-8 PMID: 15812508
  16. Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival.
    J Neurosci. 2004 May 12;24(19):4585-95 PMID: 15140930
  17. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis.
    Glia. 2003 Jan;41(1):73-80 PMID: 12465047
  18. Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis.
    Brain Res. 2004 Apr 16;1005(1-2):21-8 PMID: 15044060
  19. AC133+ umbilical cord blood progenitors demonstrate rapid self-renewal and low apoptosis.
    Br J Haematol. 2002 Nov;119(2):516-24 PMID: 12406095
  20. Adult rat and human bone marrow stromal cells differentiate into neurons.
    J Neurosci Res. 2000 Aug 15;61(4):364-70 PMID: 10931522
  21. Comparison of multi-lineage cells from human adipose tissue and bone marrow.
    Cells Tissues Organs. 2003;174(3):101-9 PMID: 12835573
  22. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential.
    J Exp Med. 2004 Jul 19;200(2):123-35 PMID: 15263023
  23. A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease.
    Exp Neurol. 2001 Sep;171(1):98-108 PMID: 11520124
  24. Hemopoietic stem cell differentiation.
    Biochim Biophys Acta. 1980 Nov 26;605(4):431-59 PMID: 7006701
  25. Pluripotency of mesenchymal stem cells derived from adult marrow.
    Nature. 2002 Jul 4;418(6893):41-9 PMID: 12077603
  26. Treatment of neural injury with marrow stromal cells.
    Lancet Neurol. 2002 Jun;1(2):92-100 PMID: 12849513
  27. From marrow to brain: expression of neuronal phenotypes in adult mice.
    Science. 2000 Dec 1;290(5497):1775-9 PMID: 11099418
  28. Bone marrow transdifferentiation in brain after transplantation: a retrospective study.
    Lancet. 2004 May 1;363(9419):1432-7 PMID: 15121406
  29. Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype.
    Stem Cells. 2005 Mar;23(3):392-402 PMID: 15749934
  30. Transplanted bone marrow generates new neurons in human brains.
    Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1364-9 PMID: 12538864
  31. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI).
    Circulation. 2002 Dec 10;106(24):3009-17 PMID: 12473544
  32. Stem and progenitor cells: the premature desertion of rigorous definitions.
    Trends Neurosci. 2003 Mar;26(3):125-31 PMID: 12591214
  33. BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.
    Mol Ther. 2004 Feb;9(2):189-97 PMID: 14759803
  34. Stem cells as a potential treatment of neurological disorders.
    Curr Opin Pharmacol. 2004 Feb;4(1):98-104 PMID: 15018846
  35. Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke.
    Cell Transplant. 2003;12(4):449-54 PMID: 12911133
  36. Becoming a new neuron in the adult olfactory bulb.
    Nat Neurosci. 2003 May;6(5):507-18 PMID: 12704391
  37. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.
    Nature. 2002 Jul 4;418(6893):50-6 PMID: 12077607
  38. Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats.
    Brain Res. 2005 Jun 28;1048(1-2):116-22 PMID: 15921661
  39. Differentiation, engraftment and functional effects of pre-treated mesenchymal stem cells in a rat myocardial infarct model.
    Acta Cardiol. 2005 Jun;60(3):277-84 PMID: 15999467
  40. Muscle-derived stem cells.
    Gene Ther. 2002 May;9(10):642-7 PMID: 12032710
  41. Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations.
    Brain Res. 2005 Feb 21;1035(1):73-85 PMID: 15713279
  42. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.
    Science. 2000 Dec 1;290(5497):1779-82 PMID: 11099419
  43. Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains.
    Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2088-93 PMID: 12576546
  44. Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats.
    Brain Res. 2004 Jun 4;1010(1-2):108-16 PMID: 15126123
  45. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial.
    Lancet. 2004 Jul 10-16;364(9429):141-8 PMID: 15246726
  46. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.
    Biochem Biophys Res Commun. 2001 Mar 23;282(1):148-52 PMID: 11263984
  47. Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia.
    Neurosci Res. 2004 Dec;50(4):459-65 PMID: 15567483
  48. Astroglia induce neurogenesis from adult neural stem cells.
    Nature. 2002 May 2;417(6884):39-44 PMID: 11986659
  49. Cell fusion is the principal source of bone-marrow-derived hepatocytes.
    Nature. 2003 Apr 24;422(6934):897-901 PMID: 12665832
  50. Expression of neural markers in human umbilical cord blood.
    Exp Neurol. 2001 Sep;171(1):109-15 PMID: 11520125
  51. "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain.
    Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7029-34 PMID: 10359833
  52. Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson's disease.
    Int J Dev Neurosci. 2004 Jun;22(4):175-83 PMID: 15245752
  53. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells.
    Nature. 1963 Feb 2;197:452-4 PMID: 13970094
  54. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus.
    J Neurosci. 2000 Dec 1;20(23):8727-35 PMID: 11102479
  55. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat.
    J Neurosci Res. 2003 Sep 15;73(6):778-86 PMID: 12949903
  56. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats.
    Exp Neurol. 2004 Nov;190(1):17-31 PMID: 15473977
  57. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.
    Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10711-6 PMID: 10485891
  58. Changing potency by spontaneous fusion.
    Nature. 2002 Apr 4;416(6880):545-8 PMID: 11932748
  59. Induction of umbilical cord blood mesenchymal stem cells into neuron-like cells in vitro.
    Int J Hematol. 2003 Oct;78(3):256-61 PMID: 14604286
  60. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model.
    J Clin Invest. 2004 Aug;114(3):330-8 PMID: 15286799
  61. Neuroectodermal differentiation from mouse multipotent adult progenitor cells.
    Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11854-60 PMID: 12925733
  62. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant.
    Nat Cell Biol. 2003 Nov;5(11):959-66 PMID: 14562057
  63. Multilineage potential of adult human mesenchymal stem cells.
    Science. 1999 Apr 2;284(5411):143-7 PMID: 10102814
  64. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.
    Exp Neurol. 2002 Mar;174(1):11-20 PMID: 11869029
  65. Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    Neurosci Lett. 2001 Dec18;316(2):67-70 PMID: 11742717
  66. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
    Nature. 2002 Apr 4;416(6880):542-5 PMID: 11932747
  67. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue.
    Spine (Phila Pa 1976). 2004 Sep 15;29(18):1971-9 PMID: 15371697
  68. Little evidence for developmental plasticity of adult hematopoietic stem cells.
    Science. 2002 Sep 27;297(5590):2256-9 PMID: 12215650
  69. Intracranial bone marrow transplantation after traumatic brain injury improving functional outcome in adult rats.
    J Neurosurg. 2001 Apr;94(4):589-95 PMID: 11302657
  70. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.
    J Neurobiol. 1999 Jan;38(1):65-81 PMID: 10027563
  71. Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord.
    J Comp Neurol. 2004 Nov 29;480(1):101-14 PMID: 15514921
  72. Neural cells derived from adult bone marrow and umbilical cord blood.
    J Neurosci Res. 2002 Sep 15;69(6):880-93 PMID: 12205681
  73. Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone.
    J Neurosci Res. 2000 Feb 1;59(3):321-31 PMID: 10679767
  74. Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage.
    Exp Neurol. 2001 Jan;167(1):48-58 PMID: 11161592
  75. Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.
    J Neurosci. 2003 Jun 15;23(12):5197-207 PMID: 12832544
  76. Bone marrow-derived mesenchymal stem cells already express specific neural proteins before any differentiation.
    Differentiation. 2004 Sep;72(7):319-26 PMID: 15554943
  77. Embryonic stem cell-derived glial precursors: a source of myelinating transplants.
    Science. 1999 Jul 30;285(5428):754-6 PMID: 10427001
  78. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation.
    J Clin Invest. 2004 Jun;113(12):1701-10 PMID: 15199405
  79. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury.
    Exp Neurol. 2003 Jun;181(2):115-29 PMID: 12781986
  80. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential.
    J Cell Sci. 2004 Jun 15;117(Pt 14):2971-81 PMID: 15173316
  81. Combining growth factors, stem cells, and gene therapy for the aging brain.
    Ann N Y Acad Sci. 2004 Jun;1019:5-14 PMID: 15246984
  82. Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype.
    J Neurosci Res. 2004 Jul 15;77(2):192-204 PMID: 15211586
Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.2006.2021
Published
2008-01-12
Pages
199-205
Language
English
Region
England
NLM ID
7503623
PMCID
PMC2605495
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.2006.2021 PMC Full Text View journal details
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