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PMID: 11099419 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.

Science (New York, N.Y.) ·Vol. 290 ·No. 5497 ·2000-12-01 ·Pages 1779-82

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR

Abstract

Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.

MeSH Terms

Animals Antigens/analysis Biomarkers/analysis Bone Marrow Cells/cytology,physiology Bone Marrow Transplantation Brain/cytology Cell Differentiation Cell Movement Female Immunoenzyme Techniques Intermediate Filament Proteins/analysis Male Mice Mice, Knockout Microscopy, Confocal Nerve Tissue Proteins/analysis,immunology Nestin Neurons/chemistry,cytology,immunology Phosphopyruvate Hydratase/analysis Stem Cell Transplantation Stem Cells/chemistry,cytology Y Chromosome

Chemicals

Antigens Biomarkers Intermediate Filament Proteins Nerve Tissue Proteins Nes protein, mouse Nestin Phosphopyruvate Hydratase

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mezey E

Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. mezey@codon.nih.gov

Chandross K J

Harta G

Maki R A

McKercher S R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.290.5497.1779

mezey@codon.nih.gov

Published

2000-12-01

Pages

1779-82

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI30656 · United States

Corrections

CommentIn

PMID: 11186385

External Links

PubMed source DOI: 10.1126/science.290.5497.1779 View journal details

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Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.

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