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PMID: 17277061 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome of the opportunistic pathogen Streptococcus sanguinis.

Journal of bacteriology ·Vol. 189 ·No. 8 ·2007-04-00 ·Pages 3166-75

Xu P, Alves JM, Kitten T, Brown A, Chen Z, Ozaki LS, Manque P, Ge X, Serrano MG, Puiu D, Hendricks S, Wang Y, Chaplin MD, Akan D, Paik S, Peterson DL, Macrina FL, Buck GA

Abstract

The genome of Streptococcus sanguinis is a circular DNA molecule consisting of 2,388,435 bp and is 177 to 590 kb larger than the other 21 streptococcal genomes that have been sequenced. The G+C content of the S. sanguinis genome is 43.4%, which is considerably higher than the G+C contents of other streptococci. The genome encodes 2,274 predicted proteins, 61 tRNAs, and four rRNA operons. A 70-kb region encoding pathways for vitamin B(12) biosynthesis and degradation of ethanolamine and propanediol was apparently acquired by horizontal gene transfer. The gene complement suggests new hypotheses for the pathogenesis and virulence of S. sanguinis and differs from the gene complements of other pathogenic and nonpathogenic streptococci. In particular, S. sanguinis possesses a remarkable abundance of putative surface proteins, which may permit it to be a primary colonizer of the oral cavity and agent of streptococcal endocarditis and infection in neutropenic patients.

MeSH Terms
Bacterial Proteins/analysis,metabolism Base Composition Dental Plaque/microbiology Gene Transfer, Horizontal Genome, Bacterial Humans Molecular Sequence Data Opportunistic Infections/microbiology RNA, Bacterial/metabolism RNA, Transfer/metabolism Streptococcal Infections/microbiology Streptococcus/genetics,pathogenicity rRNA Operon
Chemicals
Bacterial Proteins RNA, Bacterial RNA, Transfer
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Xu Ping
Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284-2030, USA.
Alves Joao M
Kitten Todd
Brown Arunsri
Chen Zhenming
Ozaki Luiz S
Manque Patricio
Ge Xiuchun
Serrano Myrna G
Puiu Daniela
Hendricks Stephanie
Wang Yingping
Chaplin Michael D
Akan Doruk
Paik Sehmi
Peterson Darrell L
Macrina Francis L
Buck Gregory A
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.01808-06
Published
2007-04-00
Epub
2007-00-02
Pages
3166-75
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC1855836
Subset
IM
Grants
NIAID NIH HHS · K02 AI054908-05 · United States
NIAID NIH HHS · R01 AI047841 · United States
NIDCR NIH HHS · DE12882 · United States
NIAID NIH HHS · K02 AI054908-01 · United States
NIAID NIH HHS · R01 AI047841-03 · United States
NIAID NIH HHS · R01 AI047841-01A1 · United States
NIAID NIH HHS · AI054908 · United States
NIAID NIH HHS · K02 AI054908-04 · United States
NIAID NIH HHS · K02 AI054908-02 · United States
NIAID NIH HHS · R01 AI047841-02 · United States
NIAID NIH HHS · AI47841 · United States
NIAID NIH HHS · K02 AI054908 · United States
NIAID NIH HHS · R01 AI047841-04A1 · United States
NIAID NIH HHS · R01 AI047841-05 · United States
NIAID NIH HHS · K02 AI054908-03 · United States
NIAID NIH HHS · R01 AI047841-06 · United States
Databases
GENBANK
CP000387
External Links
PubMed source DOI: 10.1128/JB.01808-06 PMC Full Text View journal details
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