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PMID: 1723075 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Homotypic and heterotypic serological responses to rotavirus neutralization epitopes in immunologically naive and experienced animals.

Journal of clinical microbiology ·Vol. 29 ·No. 11 ·1991-11-00 ·Pages 2668-72

Snodgrass DR, Fitzgerald TA, Campbell I, Browning GF, Scott FM, Hoshino Y, Davies RC

Abstract

Gnotobiotic or specific-pathogen-free animals with no previous exposure to rotavirus were vaccinated with strain UK, serotype G6. The highest serological response was to homologous virus; significant but lower responses occurred to viruses with either VP4 or VP7 related to that of vaccine virus; responses to other viruses were of low titer or infrequent. Adult cows vaccinated with UK virus produced increased titers of antibody to all rotavirus serotypes. The increases in titer to homologous virus and to other natural and reassortant viruses sharing VP7 with the vaccine virus were significantly higher than those to all other viruses. These results suggest the presence of common epitopes which are not well recognized in primary infections.

MeSH Terms
Animals Antibodies, Viral/biosynthesis Antigens, Viral Capsid/immunology Capsid Proteins Cattle Epitopes Germ-Free Life Neutralization Tests Rotavirus/classification,immunology Rotavirus Infections/immunology,prevention & control Sheep Viral Vaccines/immunology
Chemicals
Antibodies, Viral Antigens, Viral Capsid Proteins Epitopes VP4 protein, Rotavirus VP7 protein, Rotavirus Viral Vaccines
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Snodgrass D R
Moredun Research Institute, Edinburgh, Scotland.
Fitzgerald T A
Campbell I
Browning G F
Scott F M
Hoshino Y
Davies R C
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.29.11.2668-2672.1991
Published
1991-11-00
Pages
2668-72
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC270403
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.29.11.2668-2672.1991 PMC Full Text View journal details
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