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PMID: 1720549 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 23 ·1991-12-01 ·Pages 10735-9

Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, Rubinelli P, Smith SD, LeBeau MM, Rowley JD

Abstract

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. We have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and we describe two other, related transcripts that are upregulated in the RS4;11 cell line. We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia.

Related Genes
MLL
MeSH Terms
Adult Blotting, Northern Blotting, Southern Cell Line Child, Preschool Chromosome Banding Chromosomes, Human, Pair 11 Cloning, Molecular DNA, Neoplasm/genetics,isolation & purification Female Gene Expression/drug effects Genes Humans Karyotyping Leukemia/genetics Male Middle Aged Poly A/genetics,isolation & purification RNA/genetics,isolation & purification RNA, Messenger RNA, Neoplasm/genetics,isolation & purification Restriction Mapping Tetradecanoylphorbol Acetate/pharmacology Translocation, Genetic
Chemicals
DNA, Neoplasm RNA, Messenger RNA, Neoplasm Poly A RNA Tetradecanoylphorbol Acetate
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Ziemin-van der Poel S
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637.
McCabe N R
Gill H J
Espinosa R
Patel Y
Harden A
Rubinelli P
Smith S D
LeBeau M M
Rowley J D
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21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.23.10735
Published
1991-12-01
Pages
10735-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53005
Subset
IM
Grants
NCI NIH HHS · CA38725 · United States
NCI NIH HHS · CA42557 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1073/pnas.88.23.10735 PMC Full Text View journal details
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