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PMID: 17173542 Published · ppublish English Journal Article Review

Big roles for small GTPases in the control of directed cell movement.

The Biochemical journal ·Vol. 401 ·No. 2 ·2007-01-15 ·Pages 377-90

Charest PG, Firtel RA

Abstract

Small GTPases are involved in the control of diverse cellular behaviours, including cellular growth, differentiation and motility. In addition, recent studies have revealed new roles for small GTPases in the regulation of eukaryotic chemotaxis. Efficient chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which shed light on the molecular mechanisms by which small GTPases control directed cell migration.

MeSH Terms
Actins/metabolism Animals Cell Movement/physiology Cell Polarity/physiology Chemotaxis/physiology GTP Phosphohydrolases/physiology GTP-Binding Proteins/physiology Guanine Nucleotide Exchange Factors/physiology Microtubules/drug effects,physiology Myosins/metabolism PTEN Phosphohydrolase/metabolism Phosphatidylinositol 3-Kinases/metabolism Signal Transduction/physiology ras Proteins/physiology
Chemicals
Actins Guanine Nucleotide Exchange Factors Phosphatidylinositol 3-Kinases PTEN Phosphohydrolase GTP Phosphohydrolases GTP-Binding Proteins Myosins ras Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Charest Pascale G
Section of Cell and Developmental Biology, Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0380, USA.
Firtel Richard A
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
1470-8728
DOI
10.1042/BJ20061432
Published
2007-01-15
Pages
377-90
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1820805
Subset
IM
External Links
PubMed source DOI: 10.1042/BJ20061432 PMC Full Text View journal details
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