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PMID: 15452139 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation of WASP/WAVE proteins: making a long story short.

The Journal of cell biology ·Vol. 166 ·No. 7 ·2004-09-27 ·Pages 957-62

Bompard G, Caron E

Abstract

Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.

MeSH Terms
Actin-Related Protein 2 Actins/genetics,metabolism Animals Cytoskeletal Proteins/genetics,metabolism Humans Macromolecular Substances Microfilament Proteins/genetics,metabolism Models, Biological Monomeric GTP-Binding Proteins/genetics,metabolism Protein Processing, Post-Translational/genetics Proteins/genetics,metabolism Signal Transduction/genetics Wiskott-Aldrich Syndrome Protein Wiskott-Aldrich Syndrome Protein Family
Chemicals
ACTR2 protein, human Actin-Related Protein 2 Actins Cytoskeletal Proteins Macromolecular Substances Microfilament Proteins Proteins WAS protein, human Wiskott-Aldrich Syndrome Protein Wiskott-Aldrich Syndrome Protein Family Monomeric GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bompard Guillaume
School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK. G.Bompard@bham.ac.uk
Caron Emmanuelle
References (40)
40 references, click to expand
  1. Negative regulation of yeast WASp by two SH3 domain-containing proteins.
    Curr Biol. 2003 Jun 17;13(12):1000-8 PMID: 12814545
  2. Regulation by phosphorylation. Yet another twist in the WASP story.
    Dev Cell. 2003 Jun;4(6):772-3 PMID: 12791263
  3. WAVE2 is required for directed cell migration and cardiovascular development.
    Nature. 2003 Jul 24;424(6947):452-6 PMID: 12879075
  4. A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
    Nat Struct Biol. 2003 Aug;10(8):591-8 PMID: 12872157
  5. PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium.
    Curr Biol. 2003 Sep 2;13(17):1480-7 PMID: 12956949
  6. Molecular requirements for actin-based lamella formation in Drosophila S2 cells.
    J Cell Biol. 2003 Sep 15;162(6):1079-88 PMID: 12975351
  7. Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.
    Dev Cell. 2003 Oct;5(4):595-609 PMID: 14536061
  8. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90.
    J Biol Chem. 2003 Oct 24;278(43):42515-23 PMID: 12871950
  9. Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions.
    Curr Biol. 2003 Oct 28;13(21):1867-75 PMID: 14588242
  10. FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.
    Biochem Biophys Res Commun. 2004 Jan 16;313(3):468-74 PMID: 14697212
  11. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
    EMBO J. 2004 Feb 25;23(4):749-59 PMID: 14765121
  12. Focal adhesion kinase regulation of N-WASP subcellular localization and function.
    J Biol Chem. 2004 Mar 5;279(10):9565-76 PMID: 14676198
  13. Abi1 is essential for the formation and activation of a WAVE2 signalling complex.
    Nat Cell Biol. 2004 Apr;6(4):319-27 PMID: 15048123
  14. Purification and architecture of the ubiquitous Wave complex.
    Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4379-83 PMID: 15070726
  15. PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia.
    Nat Cell Biol. 2004 May;6(5):420-6 PMID: 15107862
  16. Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.
    Biochem J. 2004 May 15;380(Pt 1):1-17 PMID: 15040784
  17. Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
    Mol Cell Biol. 2004 Jun;24(11):4979-93 PMID: 15143189
  18. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck.
    Biochem Biophys Res Commun. 1996 Feb 15;219(2):509-14 PMID: 8605018
  19. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.
    J Biol Chem. 1998 Jan 2;273(1):291-5 PMID: 9417078
  20. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.
    EMBO J. 1998 Dec 1;17(23):6932-41 PMID: 9843499
  21. EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.
    FEBS Lett. 1998 Dec 18;441(2):181-5 PMID: 9883880
  22. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex.
    Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3739-44 PMID: 10097107
  23. Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling.
    J Biol Chem. 1999 Sep 24;274(39):27605-9 PMID: 10488099
  24. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
    EMBO J. 2003 Jul 15;22(14):3602-12 PMID: 12853475
  25. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.
    Science. 2000 Oct 27;290(5492):801-6 PMID: 11052943
  26. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
    Nature. 2000 Dec 7;408(6813):732-5 PMID: 11130076
  27. Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease.
    Gene. 2001 Jun 27;271(2):159-69 PMID: 11418237
  28. The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization.
    Genes Dev. 2000 Apr 1;14(7):863-73 PMID: 10766742
  29. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.
    EMBO J. 2000 Sep 1;19(17):4589-600 PMID: 10970852
  30. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
    Curr Biol. 2001 Oct 30;11(21):1645-55 PMID: 11696321
  31. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.
    Annu Rev Biochem. 2001;70:649-76 PMID: 11395419
  32. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.
    Nature. 2002 Aug 15;418(6899):790-3 PMID: 12181570
  33. WASp in immune-system organization and function.
    Nat Rev Immunol. 2002 Sep;2(9):635-46 PMID: 12209132
  34. Sustained activation of N-WASP through phosphorylation is essential for neurite extension.
    Dev Cell. 2002 Nov;3(5):645-58 PMID: 12431372
  35. Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
    J Biol Chem. 2002 Nov 22;277(47):45115-21 PMID: 12235133
  36. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.
    Nat Cell Biol. 2002 Dec;4(12):970-5 PMID: 12447388
  37. Cellular motility driven by assembly and disassembly of actin filaments.
    Cell. 2003 Feb 21;112(4):453-65 PMID: 12600310
  38. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
    Mol Cell. 2003 May;11(5):1215-27 PMID: 12769846
  39. Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
    Mol Cell. 2003 May;11(5):1229-39 PMID: 12769847
  40. The nucleoskeleton: lamins and actin are major players in essential nuclear functions.
    Curr Opin Cell Biol. 2003 Jun;15(3):358-66 PMID: 12787780
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200403127
Email
g.bompard@bham.ac.uk
Published
2004-09-27
Pages
957-62
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2172026
Subset
IM
Grants
Wellcome Trust · United Kingdom
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1083/jcb.200403127 PMC Full Text View journal details
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