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PMID: 17169327 Published · ppublish English Journal Article Review

Regulation of CXCR4 signaling.

Biochimica et biophysica acta ·Vol. 1768 ·No. 4 ·2007-04-00 ·Pages 952-63

Busillo JM, Benovic JL

Abstract

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression.

MeSH Terms
Amino Acid Sequence Gene Expression Regulation Humans Immunologic Deficiency Syndromes/genetics Molecular Sequence Data Neoplasms/genetics Receptors, CXCR4/genetics,metabolism Receptors, G-Protein-Coupled/genetics,metabolism Signal Transduction
Chemicals
Receptors, CXCR4 Receptors, G-Protein-Coupled
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Busillo John M
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Benovic Jeffrey L
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamem.2006.11.002
Published
2007-04-00
Epub
2006-00-10
Pages
952-63
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC1952230
Subset
IM
Grants
NIGMS NIH HHS · R01 GM044944 · United States
NIGMS NIH HHS · R01 GM044944-16 · United States
NIGMS NIH HHS · R37 GM047417 · United States
NIGMS NIH HHS · R37 GM047417-13 · United States
External Links
PubMed source DOI: 10.1016/j.bbamem.2006.11.002 PMC Full Text
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