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PMID: 17132875 Published · ppublish English Journal Article Review

Multipotent adult progenitor cell and stem cell plasticity.

Stem cell reviews ·Vol. 1 ·No. 1 ·2005-00-00 ·Pages 53-9

Jahagirdar BN, Verfaillie CM

Abstract

Stem cells are defined by their biological function. A stem cell is an undifferentiated cell that self-renews to maintain the stem cell pool and at the single-cell level differentiates into more than one mature, functional cell. In addition, when transplanted, a stem cell should be capable of replacing a damaged organ or tissue for the lifetime of the recipient. Some would argue that stem cells should also be capable of functionally integrating into nondamaged tissues. Stem cells are critical to both embryogenesis and postnatal life.

MeSH Terms
Adult Blastocyst/cytology,physiology Cell Differentiation Cell Separation Humans Mesoderm/cytology,physiology Stem Cell Transplantation Stem Cells/cytology,physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jahagirdar Balkrishna N
University of Minnesota and Minneapolis VA Medical Center, MN, USA.
Verfaillie Catherine M
References (81)
81 references, click to expand
  1. Purification and characterization of mouse hematopoietic stem cells.
    Science. 1988 Jul 1;241(4861):58-62 PMID: 2898810
  2. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos.
    Immunity. 1998 Jun;8(6):761-9 PMID: 9655490
  3. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells.
    Science. 2001 Feb 2;291(5505):868-71 PMID: 11157165
  4. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors.
    Blood. 2000 Feb 1;95(3):952-8 PMID: 10648408
  5. Mesoangioblasts--vascular progenitors for extravascular mesodermal tissues.
    Curr Opin Genet Dev. 2003 Oct;13(5):537-42 PMID: 14550421
  6. Proliferation and differentiation of ductular progenitor cells and littoral cells during the regeneration of the rat liver to CCl4/2-AAF injury.
    Histol Histopathol. 2002 Jan;17 (1):65-81 PMID: 11813887
  7. Cultivation of human keratinocyte stem cells: current and future clinical applications.
    Med Biol Eng Comput. 1998 Nov;36(6):778-90 PMID: 10367472
  8. Somatic stem cell plasticity: current evidence and emerging concepts.
    Exp Hematol. 2001 Dec;29(12):1361-70 PMID: 11750094
  9. Definitive hematopoiesis is autonomously initiated by the AGM region.
    Cell. 1996 Sep 20;86(6):897-906 PMID: 8808625
  10. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.
    Nat Biotechnol. 2000 Jun;18(6):675-9 PMID: 10835609
  11. Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.
    Blood. 2004 Mar 1;103(5):1647-52 PMID: 14630823
  12. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.
    Science. 2001 May 18;292(5520):1389-94 PMID: 11326082
  13. Immunohistochemical identification of proliferating cells following dimethylnitrosamine-induced liver injury.
    Liver. 1990 Oct;10(5):278-81 PMID: 2255228
  14. Hemangioblast development and regulation.
    Biochem Cell Biol. 1998;76(6):947-56 PMID: 10392708
  15. Isolation of multipotent adult stem cells from the dermis of mammalian skin.
    Nat Cell Biol. 2001 Sep;3(9):778-84 PMID: 11533656
  16. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.
    Cell Transplant. 2003;12(3):201-13 PMID: 12797375
  17. Rethinking somatic stem cell plasticity.
    Nat Biotechnol. 2002 May;20(5):425 PMID: 11981543
  18. The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues.
    Development. 2002 Jun;129(11):2773-83 PMID: 12015303
  19. Growth and differentiation in culture of clonogenic hepatocytes that express both phenotypes of hepatocytes and biliary epithelial cells.
    Am J Pathol. 1996 Nov;149(5):1593-605 PMID: 8909249
  20. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies.
    Bone. 1992;13(1):69-80 PMID: 1316137
  21. Isolation of putative progenitor endothelial cells for angiogenesis.
    Science. 1997 Feb 14;275(5302):964-7 PMID: 9020076
  22. Embryonic stem cell lines derived from human blastocysts.
    Science. 1998 Nov 6;282(5391):1145-7 PMID: 9804556
  23. Establishment in culture of pluripotential cells from mouse embryos.
    Nature. 1981 Jul 9;292(5819):154-6 PMID: 7242681
  24. Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts.
    Science. 2003 Jul 25;301(5632):487-92 PMID: 12855815
  25. Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice.
    Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2414-9 PMID: 8637888
  26. Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis.
    Blood. 1999 Feb 15;93(4):1253-63 PMID: 9949168
  27. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro.
    Nat Biotechnol. 2000 Apr;18(4):399-404 PMID: 10748519
  28. Hematopoietic colony-forming cells derived from human embryonic stem cells.
    Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10716-21 PMID: 11535826
  29. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain.
    Exp Hematol. 2002 Aug;30(8):896-904 PMID: 12160841
  30. Liver stem cells: a two compartment system.
    Curr Opin Cell Biol. 1998 Dec;10(6):710-5 PMID: 9914178
  31. A common precursor for hematopoietic and endothelial cells.
    Development. 1998 Feb;125(4):725-32 PMID: 9435292
  32. Mammalian neural stem cells.
    Science. 2000 Feb 25;287(5457):1433-8 PMID: 10688783
  33. Muscle stem cells.
    J Pathol. 2002 Jul;197(4):457-67 PMID: 12115862
  34. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro.
    Blood. 1989 Oct;74(5):1563-70 PMID: 2790186
  35. Marrow stromal cells as stem cells for nonhematopoietic tissues.
    Science. 1997 Apr 4;276(5309):71-4 PMID: 9082988
  36. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors.
    Nature. 2000 Nov 2;408(6808):92-6 PMID: 11081514
  37. Isolation of a primate embryonic stem cell line.
    Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7844-8 PMID: 7544005
  38. Pluripotency of mesenchymal stem cells derived from adult marrow.
    Nature. 2002 Jul 4;418(6893):41-9 PMID: 12077603
  39. Multilineage cells from human adipose tissue: implications for cell-based therapies.
    Tissue Eng. 2001 Apr;7(2):211-28 PMID: 11304456
  40. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells.
    Blood. 2001 Nov 1;98(9):2615-25 PMID: 11675329
  41. Stem cell plasticity?
    Neuron. 2002 Aug 1;35(3):415-8 PMID: 12165465
  42. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.
    J Clin Invest. 2002 May;109(10):1291-302 PMID: 12021244
  43. Translating stem and progenitor cell biology to the clinic: barriers and opportunities.
    Science. 2000 Feb 25;287(5457):1442-6 PMID: 10688785
  44. Hepatic stem cells.
    J Hepatol. 1998 Oct;29(4):676-82 PMID: 9824279
  45. Histone deacetylase activity is required for embryonic stem cell differentiation.
    Genesis. 2004 Jan;38(1):32-8 PMID: 14755802
  46. Stem cells in gastrointestinal epithelium: numbers, characteristics and death.
    Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):821-30 PMID: 9684279
  47. Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion.
    Blood. 1994 Jul 1;84(1):10-9 PMID: 7517203
  48. Stem cell plasticity.
    Br J Haematol. 2003 Sep;122(6):877-91 PMID: 12956757
  49. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
    Science. 1996 Jul 12;273(5272):242-5 PMID: 8662508
  50. Multipotent progenitor cells in the adult dentate gyrus.
    J Neurobiol. 1998 Aug;36(2):249-66 PMID: 9712308
  51. [Stromal bone marrow cells and the hematopoietic microenvironment].
    Arkh Patol. 1982;44(10):3-11 PMID: 7181706
  52. Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.
    Mol Cell Biol. 2004 Oct;24(20):8862-71 PMID: 15456861
  53. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors.
    Blood. 1994 Dec 15;84(12):4164-73 PMID: 7994030
  54. Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells.
    Ann N Y Acad Sci. 2001 Jun;938:231-3; discussion 233-5 PMID: 11458512
  55. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8078-83 PMID: 12048252
  56. Liver regeneration: from laboratory to clinic.
    Liver Transpl. 2001 Oct;7(10):835-44 PMID: 11679980
  57. Molecular basis of transdifferentiation of pancreas to liver.
    Nat Cell Biol. 2000 Dec;2(12):879-87 PMID: 11146651
  58. Origin of endothelial progenitors in human postnatal bone marrow.
    J Clin Invest. 2002 Feb;109 (3):337-46 PMID: 11827993
  59. Changing potency by spontaneous fusion.
    Nature. 2002 Apr 4;416(6880):545-8 PMID: 11932748
  60. Demethylation of the zygotic paternal genome.
    Nature. 2000 Feb 3;403(6769):501-2 PMID: 10676950
  61. Stem cell plasticity--building the brain of our dreams.
    Nat Rev Neurosci. 2001 Jul;2(7):513-20 PMID: 11433376
  62. Pluripotent embryonic stem cell lines can be derived from tw5/tw5 blastocysts.
    Nature. 1982 Aug 19;298(5876):750-3 PMID: 7110310
  63. Neuroectodermal differentiation from mouse multipotent adult progenitor cells.
    Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11854-60 PMID: 12925733
  64. Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting.
    Genes Dev. 1992 Dec;6(12B):2536-41 PMID: 1340468
  65. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice.
    Development. 1999 Jul;126(13):3015-25 PMID: 10357944
  66. Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers.
    Differentiation. 1991 Dec;48(3):173-82 PMID: 1725163
  67. Multilineage potential of adult human mesenchymal stem cells.
    Science. 1999 Apr 2;284(5411):143-7 PMID: 10102814
  68. Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.
    Exp Neurol. 2002 Mar;174(1):11-20 PMID: 11869029
  69. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.
    J Clin Invest. 2001 Aug;108(3):407-14 PMID: 11489934
  70. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
    Nature. 2002 Apr 4;416(6880):542-5 PMID: 11932747
  71. Adult stem cell plasticity: fact or artifact?
    Annu Rev Cell Dev Biol. 2003;19:1-22 PMID: 14570561
  72. Ethical guidelines for human embryonic stem cell research.
    Kennedy Inst Ethics J. 2004 Mar;14(1):47-54 PMID: 15250114
  73. Hepatic maturation in differentiating embryonic stem cells in vitro.
    FEBS Lett. 2001 May 18;497(1):15-9 PMID: 11376655
  74. Isolation, short-term culture, and transplantation of small hepatocyte-like progenitor cells from retrorsine-exposed rats.
    Transplantation. 2002 Apr 27;73(8):1236-43 PMID: 11981414
  75. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.
    Diabetes. 2000 Feb;49(2):157-62 PMID: 10868930
  76. Identification of a neural stem cell in the adult mammalian central nervous system.
    Cell. 1999 Jan 8;96(1):25-34 PMID: 9989494
  77. Human embryonic stem cell and embryonic germ cell lines.
    Trends Biotechnol. 2000 Feb;18(2):53-7 PMID: 10652509
  78. Human embryonic stem cells.
    J Cell Sci. 2000 Jan;113 ( Pt 1):5-10 PMID: 10591620
  79. Embryonic stem cell-derived glial precursors: a source of myelinating transplants.
    Science. 1999 Jul 30;285(5428):754-6 PMID: 10427001
  80. Plasticity of adult stem cells.
    Cell. 2004 Mar 5;116(5):639-48 PMID: 15006347
  81. Multilineage differentiation from human embryonic stem cell lines.
    Stem Cells. 2001;19(3):193-204 PMID: 11359944
Article Info
Journal
Stem cell reviews
Abbr.
Stem Cell Rev
ISSN
1550-8943
DOI
10.1385/SCR:1:1:053
Published
2005-00-00
Pages
53-9
Language
English
Region
United States
NLM ID
101255952
Subset
IM
External Links
PubMed source DOI: 10.1385/SCR:1:1:053 View journal details
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