Home LiteratureArticle Details
PMID: 17130151 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The mouse Gene Expression Database (GXD): 2007 update.

Nucleic acids research ·Vol. 35 ·No. Database issue ·2007-01-00 ·Pages D618-23

Smith CM, Finger JH, Hayamizu TF, McCright IJ, Eppig JT, Kadin JA, Richardson JE, Ringwald M

Abstract

The Gene Expression Database (GXD) provides the scientific community with an extensive and easily searchable database of gene expression information about the mouse. Its primary emphasis is on developmental studies. By integrating different types of expression data, GXD aims to provide comprehensive information about expression patterns of transcripts and proteins in wild-type and mutant mice. Integration with the other Mouse Genome Informatics (MGI) databases places the gene expression information in the context of genetic, sequence, functional and phenotypic information, enabling valuable insights into the molecular biology that underlies developmental and disease processes. In recent years the utility of GXD has been greatly enhanced by a large increase in data content, obtained from the literature and provided by researchers doing large-scale in situ and cDNA screens. In addition, we have continued to refine our query and display features to make it easier for users to interrogate the data. GXD is available through the MGI web site at http://www.informatics.jax.org/ or directly at http://www.informatics.jax.org/menus/expression_menu.shtml.

MeSH Terms
Animals Databases, Genetic Gene Expression Internet Mice/embryology,genetics,metabolism Proteins/genetics,metabolism RNA, Messenger/metabolism User-Computer Interface
Chemicals
Proteins RNA, Messenger
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Smith Constance M
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Finger Jacqueline H
Hayamizu Terry F
McCright Ingeborg J
Eppig Janan T
Kadin James A
Richardson Joel E
Ringwald Martin
References (43)
43 references, click to expand
  1. The Mouse Gene Expression Database (GXD).
    Nucleic Acids Res. 2001 Jan 1;29(1):98-101 PMID: 11125060
  2. The Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data.
    Genome Biol. 2005;6(3):R29 PMID: 15774030
  3. The Mouse SAGE Site: database of public mouse SAGE libraries.
    Nucleic Acids Res. 2004 Jan 1;32(Database issue):D482-3 PMID: 14681462
  4. The transcriptional landscape of the mammalian genome.
    Science. 2005 Sep 2;309(5740):1559-63 PMID: 16141072
  5. Human chromosome 21 gene expression atlas in the mouse.
    Nature. 2002 Dec 5;420(6915):582-6 PMID: 12466854
  6. The Rat Genome Database (RGD): developments towards a phenome database.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D485-91 PMID: 15608243
  7. A database for mouse development.
    Science. 1994 Sep 30;265(5181):2033-4 PMID: 8091224
  8. Mouse brain organization revealed through direct genome-scale TF expression analysis.
    Science. 2004 Dec 24;306(5705):2255-7 PMID: 15618518
  9. Verification and initial annotation of the NIA mouse 15K cDNA clone set.
    Nat Genet. 2001 May;28(1):17-8 PMID: 11326268
  10. The ARKdb: genome databases for farmed and other animals.
    Nucleic Acids Res. 2001 Jan 1;29(1):106-10 PMID: 11125062
  11. Connecting sequence and biology in the laboratory mouse.
    Genome Res. 2003 Jun;13(6B):1505-19 PMID: 12819150
  12. A gene expression map of human chromosome 21 orthologues in the mouse.
    Nature. 2002 Dec 5;420(6915):586-90 PMID: 12466855
  13. InterPro, progress and status in 2005.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D201-5 PMID: 15608177
  14. Entrez Gene: gene-centered information at NCBI.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D54-8 PMID: 15608257
  15. GenBank.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D16-20 PMID: 16381837
  16. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.
    Genome Res. 2002 Dec;12(12):1999-2003 PMID: 12466305
  17. The mammalian gene collection.
    Science. 1999 Oct 15;286(5439):455-7 PMID: 10521335
  18. Ensembl 2006.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D556-61 PMID: 16381931
  19. GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
    Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 PMID: 14681479
  20. Genomic analysis of mouse retinal development.
    PLoS Biol. 2004 Sep;2(9):E247 PMID: 15226823
  21. EMAGE: a spatial database of gene expression patterns during mouse embryo development.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D637-41 PMID: 16381949
  22. The Mouse Genome Database (MGD): updates and enhancements.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D562-7 PMID: 16381933
  23. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    Genome Res. 2004 Oct;14(10B):2121-7 PMID: 15489334
  24. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D514-7 PMID: 15608251
  25. The TIGR Gene Indices: clustering and assembling EST and known genes and integration with eukaryotic genomes.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D71-4 PMID: 15608288
  26. A gene atlas of the mouse and human protein-encoding transcriptomes.
    Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7 PMID: 15075390
  27. The Gene Ontology (GO) project in 2006.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D322-6 PMID: 16381878
  28. Database resources of the National Center for Biotechnology Information.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D173-80 PMID: 16381840
  29. Gene expression nervous system atlas (GENSAT).
    Nat Neurosci. 2004 May;7(5):483 PMID: 15114362
  30. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
    BMC Dev Biol. 2005;5:14 PMID: 16033648
  31. The Stanford Microarray Database accommodates additional microarray platforms and data formats.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D580-2 PMID: 15608265
  32. An anatomy of normal and malignant gene expression.
    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11287-92 PMID: 12119410
  33. ArrayExpress--a public repository for microarray gene expression data at the EBI.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D553-5 PMID: 15608260
  34. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
    Nature. 2002 Dec 5;420(6915):563-73 PMID: 12466851
  35. The Universal Protein Resource (UniProt): an expanding universe of protein information.
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D187-91 PMID: 16381842
  36. An internet-accessible database of mouse developmental anatomy based on a systematic nomenclature.
    Mech Dev. 1998 Jun;74(1-2):111-20 PMID: 9651497
  37. GXD: a Gene Expression Database for the laboratory mouse: current status and recent enhancements. The Gene Expresison Database group.
    Nucleic Acids Res. 2000 Jan 1;28(1):115-9 PMID: 10592197
  38. GXD: a gene expression database for the laboratory mouse. The Gene Expression Database Group.
    Nucleic Acids Res. 1999 Jan 1;27(1):106-12 PMID: 9847152
  39. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
    PLoS Biol. 2006 Apr;4(4):e86 PMID: 16602821
  40. NCBI GEO: mining millions of expression profiles--database and tools.
    Nucleic Acids Res. 2005 Jan 1;33(Database issue):D562-6 PMID: 15608262
  41. The mouse genome database: a resource for today and tomorrow.
    Lab Anim (NY). 2000 Mar;29(3):39-43 PMID: 11375645
  42. The mouse Gene Expression Database (GXD): updates and enhancements.
    Nucleic Acids Res. 2004 Jan 1;32(Database issue):D568-71 PMID: 14681482
  43. The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003.
    Nucleic Acids Res. 2003 Jan 1;31(1):365-70 PMID: 12520024
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
Published
2007-01-00
Epub
2006-00-27
Pages
D618-23
Language
English
Region
England
NLM ID
0411011
PMCID
PMC1716716
Subset
IM
Grants
NICHD NIH HHS · R01 HD033745 · United States
NICHD NIH HHS · HD033745 · United States
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com