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PMID: 1706475 Published · ppublish English Journal Article

Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta.

Molecular and cellular biology ·Vol. 11 ·No. 4 ·1991-04-00 ·Pages 2315-8

Hohmann HP, Kolbeck R, Remy R, van Loon AP

Abstract

No correlation exists in HL60 cells between NF-kappa B activation by tumor necrosis factor (TNF alpha) and TNF beta and intracellular levels of cyclic AMP. Cyclic AMP levels did not increase upon treatment of cells with each of these cytokines, although NF-kappa B was activated. Forskolin or 1-isobutyl-3-methylxanthine drastically increased intracellular levels of cyclic AMP, but neither activated NF-kappa B nor influenced TNF-induced NF-kappa B activation.

MeSH Terms
1-Methyl-3-isobutylxanthine/pharmacology Colforsin/pharmacology Cyclic AMP/metabolism Gene Expression Regulation Humans Kinetics Leukemia NF-kappa B/genetics Tumor Cells, Cultured Tumor Necrosis Factor-alpha/pharmacology
Chemicals
NF-kappa B Tumor Necrosis Factor-alpha Colforsin Cyclic AMP 1-Methyl-3-isobutylxanthine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hohmann H P
Central Research Units, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Kolbeck R
Remy R
van Loon A P
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34 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.11.4.2315-2318.1991
Published
1991-04-00
Pages
2315-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC359939
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.11.4.2315-2318.1991 PMC Full Text View journal details
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