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PMID: 1701102 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

A simple model for multi-ion permeation. Single-vacancy conduction in a simple pore model.

Biophysical journal ·Vol. 58 ·No. 4 ·1990-10-00 ·Pages 975-84

Schumaker MF, MacKinnon R

Abstract

Recent experimental evidence suggests that certain membrane channels operate in a nearly ion-saturated state. We therefore consider a "single-vacancy" model of ion permeation: if a channel has n conducting sites, it will contain either n or n-1 ions. Simple analytical expressions for the current, conductance, and reversal potential under bi-ionic conditions are derived. The results are compared with those of single ion models and recent experiments on Ca2(+)-activated K+ channels.

MeSH Terms
Biophysical Phenomena Biophysics Electric Conductivity Electrochemistry Energy Metabolism Ion Channels/metabolism Membrane Potentials Models, Biological Permeability
Chemicals
Ion Channels
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schumaker M F
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254.
MacKinnon R
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25 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(90)82442-5
Published
1990-10-00
Pages
975-84
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1281043
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(90)82442-5 PMC Full Text View journal details
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