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PMID: 16941108 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Current topics in human SLE genetics.

Springer seminars in immunopathology ·Vol. 28 ·No. 2 ·2006-10-00 ·Pages 97-107

Wong M, Tsao BP

Abstract

Susceptibility to systemic lupus erythematosus (SLE) depends on genetic and environmental factors. Genome scan studies have identified eight chromosomal regions with significant linkage to SLE that are confirmed by individual cohorts, suggesting that susceptibility genes may be identified within each of these loci. Linkage studies and single nucleotide polymorphisms (SNPs) have led to the identification of positional candidate genes, and their functional allelic variants have demonstrated molecular pathogenesis of the disease. The discovery of positional candidate genes that are associated with various autoimmune diseases signifies a common pathway in the mechanism of these diseases. Copy polymorphisms in susceptibility genes provide evidence in how genetic plasticity affects complex phenotypes as seen in SLE.

MeSH Terms
Genetic Linkage Genetic Predisposition to Disease Genome, Human Humans Lupus Erythematosus, Systemic/genetics,physiopathology Phenotype Polymorphism, Single Nucleotide Quantitative Trait Loci
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wong Maida
Division of Rheumatology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1670, USA.
Tsao Betty P
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Article Info
Journal
Springer seminars in immunopathology
Abbr.
Springer Semin Immunopathol
ISSN
0344-4325
DOI
10.1007/s00281-006-0031-6
Published
2006-10-00
Epub
2006-00-29
Pages
97-107
Language
English
Region
Germany
NLM ID
7910384
Subset
IM
Grants
NIAMS NIH HHS · AR43814 · United States
External Links
PubMed source DOI: 10.1007/s00281-006-0031-6
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